Matovic R, Bihelovic F, Gruden-Pavlovic M, Saicic R N
ICTM-Center for Chemistry, Njegoseva 12, Belgrade.
Org Biomol Chem. 2014 Oct 21;12(39):7682-5. doi: 10.1039/c4ob01436g. Epub 2014 Aug 28.
The total synthesis of desmethylabyssomicin C analogue 1 was accomplished using diastereotopos-selective ring closing metathesis and Nozaki-Hiyama-Kishi cyclization as the key steps. The synthetic analogue retained its antibacterial activity against methicillin-resistant S. aureus strains, whereas its cytotoxicity decreased for three orders of magnitude, as compared to atrop-abyssomicin C.
去甲基深海霉素C类似物1的全合成以非对映体选择性闭环复分解反应和野崎-桧山-岸环化反应为关键步骤完成。与阿托-深海霉素C相比，该合成类似物保留了对耐甲氧西林金黄色葡萄球菌菌株的抗菌活性，但其细胞毒性降低了三个数量级。
