Moriai T, Makino T T, Ishii K
Second Department of Internal Medicine, Asahikawa Medical College, Hokkaido, Japan.
Anticancer Res. 1989 Nov-Dec;9(6):1799-804.
Fifteen patients with carcinoma of the pancreas were treated with intratumoral injection of mitomycin-C adsorbed by activated carbon particles (MMC-CH) under ultrasound guidance. Following the treatment, in 6 out of 13 patients, the serum CA 19-9 declined to 10-75% of that before the treatment. The pain was alleviated in 8 out 13 patients, and in 5 out of 8 of these patients the serum CA 19-9 declined. In one case treated with MMC-CH before total pancreatectomy, charcoal deposits were found in the tumor and in 17 regional lymph nodes along with degeneration of cancer cells around the deposited charcoal. The results indicate that intratumoral injection of MMC-CH might be one of the methods for the treatment of advanced pancreatic cancer.
15例胰腺癌患者在超声引导下接受了瘤内注射活性炭颗粒吸附的丝裂霉素C（MMC-CH）治疗。治疗后，13例患者中有6例血清CA 19-9降至治疗前的10%-75%。13例患者中有8例疼痛得到缓解，其中8例中的5例血清CA 19-9下降。在1例全胰切除术前行MMC-CH治疗的患者中，在肿瘤及17个区域淋巴结中发现了炭沉积，同时沉积炭周围的癌细胞发生退变。结果表明，瘤内注射MMC-CH可能是治疗晚期胰腺癌的方法之一。
