Voisin P, Eyl V, Muller S, Donner M, Maugras M, Stoltz J F
Unité 284, I.N.S.E.R.M., Vandoeuvre-lès-Nancy.
C R Acad Sci III. 1989;310(3):103-8.
An hybridoma cell line cultivated in flasks has been used as a model to study the loss of cell viability in high density cell cultures. Cell cycle analysis by cytofluorimetry has shown that a new hypochromosomic cell population appeared as soon as the viability began to decrease. However there is no evidence that this new population is constituted of dead cells.
培养在培养瓶中的杂交瘤细胞系已被用作研究高密度细胞培养中细胞活力丧失的模型。通过细胞荧光测定法进行的细胞周期分析表明，一旦活力开始下降，就会出现一个新的低染色体细胞群体。然而，没有证据表明这个新群体是由死细胞构成的。
