天然人肿瘤坏死因子的体内抗肿瘤机制涉及T细胞介导的免疫途径。
In vivo antitumor mechanism of natural human tumor necrosis factor involving a T cell-mediated immunological route.
作者信息
Asami T, Imai M, Tanaka Y, Hosaka Y, Kato K, Nakamura N, Horisawa Y, Ashida Y, Kanamori T, Nobuhara M
机构信息
Biosciences Research Laboratory, Mochida Pharmaceutical Co., Ltd., Tokyo.
出版信息
Jpn J Cancer Res. 1989 Dec;80(12):1161-4. doi: 10.1111/j.1349-7006.1989.tb01648.x.
We have investigated the in vivo antitumor mechanism of natural human tumor necrosis factor (n-TNF) isolated from a culture of human leukemic B cell line (BALL-1), especially its action as an immunomodulator, and found that the in vivo antitumor effect of n-TNF on Meth A sarcoma implanted in BALB/c mice pretreated with monoclonal antibody against T cell-specific surface antigen (Thy-1) was significantly diminished. Furthermore, when BALB/c mice were treated with T cell subset-specific monoclonal antibodies, anti-L3T4 or anti-Lyt-2.2, the antitumor effect of n-TNF on Meth A sarcoma was significantly reduced. Therefore, it was suggested that the in vivo antitumor mechanism of n-TNF might involve a T cell-mediated immunological route.
我们研究了从人白血病B细胞系（BALL-1）培养物中分离出的天然人肿瘤坏死因子（n-TNF）的体内抗肿瘤机制，特别是其作为免疫调节剂的作用，发现n-TNF对用抗T细胞特异性表面抗原（Thy-1）单克隆抗体预处理的BALB/c小鼠体内植入的Meth A肉瘤的抗肿瘤作用显著减弱。此外，当用T细胞亚群特异性单克隆抗体抗L3T4或抗Lyt-2.2处理BALB/c小鼠时，n-TNF对Meth A肉瘤的抗肿瘤作用也显著降低。因此，提示n-TNF的体内抗肿瘤机制可能涉及T细胞介导的免疫途径。
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