Teti D V, Cavallaro A, Valenti A, Santarpia G, Sofo V, Misefari A
Institute of General Pathology, University of Messina, Medical School, Italy.
Immunopharmacol Immunotoxicol. 1989;11(4):687-700. doi: 10.3109/08923978909005395.
It is shown that a short incubation of peripheral human lymphocytes with PGE2 is able to reduce the B cell differentiation induced by PWM. The target of PGE2 action appears to belong to T lymphocytes, since the treatment of non-T cells is uneffective in reducing the immune response. Both OKT4+ and OKT8+ subsets are sensitive to PGE2. Data concerning the role of endogenous as well as exogenous PGE2 either on unfractionated or fractionated OKT4+, OKT8+ and non-T lymphocytes are also discussed. The PGE2 inhibition on immunoglobulin synthesis in PWM-stimulated cultures seems to be mediated by a complex effect on both the T cell subsets.
研究表明，人外周血淋巴细胞与前列腺素E2（PGE2）短时间孵育能够降低由美洲商陆有丝分裂原（PWM）诱导的B细胞分化。PGE2的作用靶点似乎属于T淋巴细胞，因为对非T细胞的处理在降低免疫反应方面无效。OKT4 +和OKT8 +亚群均对PGE2敏感。还讨论了内源性和外源性PGE2对未分级或分级的OKT4 +、OKT8 +和非T淋巴细胞作用的数据。PGE2对PWM刺激培养物中免疫球蛋白合成的抑制作用似乎是由对两个T细胞亚群的复杂作用介导的。
