Martinbiancho Jacqueline, Zuckermann Joice, Dos Santos Luciana, Silva Mariane M
Pharmacy Service, Hospital de Clínicas de Porto Alegre-RS ( Brazil ).
Drug Information Center of the Hospital de Clínicas de Porto Alegre-RS ( Brazil ).
Pharm Pract (Granada). 2007 Oct;5(4):157-61. doi: 10.4321/s1886-36552007000400003.
The expected therapeutic response may be affected by the presence of drug interactions. With the high number of reports on new drug interactions, it has been difficult for health professionals to keep constantly updated. For this reason, computer systems have helped identify such interactions.
To verify the rate and profile of drug interactions in medical prescriptions to hospitalized pediatric patients.
A descriptive study investigated prescriptions to hospitalized pediatric patients. The study included patients between 0 and 12 years old, containing 4 or more drugs in their prescriptions. The analysis of interaction and incompatibility possibilities in prescribed drugs used Micromedex / Drug-Reax® program.
From 2005 to 2006, 3,170 patients were investigated, and 11,181 prescriptions were analyzed, a mean value of 3.5 prescriptions/patient. In total, 6,857 drug interactions were found, which corresponds to 1.9 interaction/prescription. Among them, relevance to ampicillin and gentamicin, found in 220 (3.2%) prescriptions. In total, 2,411 drug incompatibilities in via y were found, a mean value of 0.5/prescription, with emphasis on vancomycin and cefepime, found in 243 (10.0%) prescriptions.
The presence of drug interactions is a permanent risk in hospitals. This way, the utilization of computer programs, pharmacotherapy monitoring of patients and the pharmacist presence in the multidisciplinary team are some manners of contributing to hospitalized patients' treatment.
预期的治疗反应可能会受到药物相互作用的影响。随着关于新药相互作用的报告数量众多，医疗专业人员很难持续了解最新情况。因此，计算机系统有助于识别此类相互作用。
核实住院儿科患者医疗处方中药物相互作用的发生率和特征。
一项描述性研究调查了住院儿科患者的处方。该研究纳入了0至12岁的患者，其处方中包含4种或更多药物。使用Micromedex / Drug-Reax®程序分析处方药中相互作用和不相容性的可能性。
2005年至2006年，共调查了3170名患者，分析了11181张处方，平均每位患者3.5张处方。总共发现了6857例药物相互作用，即每张处方1.9例相互作用。其中，氨苄西林和庆大霉素的相关性在220张（3.2%）处方中被发现。总共发现了2411例静脉用药不相容性，平均每张处方0.5例，其中万古霉素和头孢吡肟的不相容性在243张（10.0%）处方中被发现。
药物相互作用的存在是医院中一个长期存在的风险。因此，利用计算机程序、对患者进行药物治疗监测以及药剂师参与多学科团队是有助于住院患者治疗的一些方式。
