Qorraj-Bytyqi Hasime, Hoxha Rexhep, Krasniqi Shaip, Bahtiri Elton, Kransiqi Valon
Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo, Yugoslavia.
J Pharmacol Pharmacother. 2012 Oct;3(4):304-7. doi: 10.4103/0976-500X.103686.
To investigate the prevalence of the major drug interactions in children and verify the rate and profile of drug interactions in hospitalized pediatric patients.
A retrospective study was designed and data collected from the files of hospitalized children in Pulmonology, Nephrology, and Gastroenterology wards of a Pediatric Clinic, from July 1999 to 2004.
From the analyzed material, we detected 34 cases of interactions, of which 1 was pharmacodynamics interaction, 13 were pharmacokinetic interactions, and 20 of unknown mechanisms. According to the rate of significance, 4 cases were categorized in the first significance rate of interaction, 18 cases in the second significance rate, 1 case of the third significance rate, 4 cases of the fourth significance rate, and 7 cases of the fifth significance rate. According to onset of cases, 33 cases were of delayed onset, and according to severity of interactions, in 7 cases we noticed major severity interaction, in 19 cases moderate severity and in 8 cases minor severity.
The presence of drug interactions is a permanent risk in the pediatric clinic. Then, we can conclude that continued education, computer system for prescriptions, pharmacotherapy monitoring of patients, and the pharmacist participation in the multidisciplinary team are some manners of improving the treatment to hospitalized patients.
调查儿童中主要药物相互作用的发生率，并核实住院儿科患者药物相互作用的发生率及情况。
设计了一项回顾性研究，收集了1999年7月至2004年期间一家儿科诊所肺病科、肾病科和胃肠病科住院儿童病历中的数据。
从分析的材料中，我们检测到34例相互作用，其中1例为药效学相互作用，13例为药代动力学相互作用，20例机制不明。根据显著性发生率，4例归类为第一显著性相互作用发生率，18例为第二显著性发生率，1例为第三显著性发生率，4例为第四显著性发生率，7例为第五显著性发生率。根据病例发生时间，33例为延迟发生，根据相互作用的严重程度，7例为严重相互作用，19例为中度严重程度，8例为轻度严重程度。
药物相互作用的存在是儿科诊所的一个长期风险。因此，我们可以得出结论，继续教育、处方计算机系统、患者药物治疗监测以及药剂师参与多学科团队是改善住院患者治疗的一些方式。
