嗜热吸水链霉菌引起的外源性过敏性肺泡炎和肺纤维化的发病机制。

Pathogenesis of extrinsic allergic alveolitis and pulmonary fibrosis induced by streptomyces thermohygroscopicus.

作者信息

Che D Y, Liu S C, Huang X Z

出版信息

Chin Med J (Engl). 1989 Jul;102(7):563-7.

Abstract

There were 48 strains of thermophilic actinomyces isolated from the specimens of mouldy hay and sputum of the patients suffering from farmer's lung (FL). Streptomyces thermohygroscopicus (STHs), one strain of them, was used for this investigation. The microorganisms were injected into the lungs of rabbits and rats by thyrocrico- or tracheocentesis. The results showed that the pathological changes in the lungs including macrophage alveolitis, granuloma formation and diffuse interstitial were similar to that induced by other thermophilic actinomyces. IgG and C3 deposition in the lesions were also observed by immunofluorescence examination. Specific immunocomplexes in the sera of some animals were detected by ELISA with the STH-antisera. The results suggested that STHs was possibly one of the pathogens responsible for FL in China's countryside.

摘要

从发霉干草标本和农民肺（FL）患者痰液中分离出48株嗜热放线菌。其中一株嗜热吸水链霉菌（STHs）用于本研究。通过甲状软骨-环状软骨穿刺或气管穿刺将这些微生物注入兔和大鼠的肺部。结果显示，肺部的病理变化包括巨噬细胞肺泡炎、肉芽肿形成和弥漫性间质改变，与其他嗜热放线菌诱导的变化相似。通过免疫荧光检查还观察到病变部位有IgG和C3沉积。用STH抗血清通过ELISA检测了一些动物血清中的特异性免疫复合物。结果表明，STHs可能是中国农村地区FL的病原体之一。