Yilmaz Lutfu Safak, Walhout Albertha J M
Program in Systems Biology, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Program in Systems Biology, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Trends Genet. 2014 Nov;30(11):496-503. doi: 10.1016/j.tig.2014.07.010. Epub 2014 Aug 26.
Micronutrients are required in small proportions in a diet to carry out key metabolic roles for biomass and energy production. Humans receive micronutrients either directly from their diet or from gut microbiota that metabolize other nutrients. The nematode Caenorhabditis elegans and its bacterial diet provide a relatively simple and genetically tractable model to study both direct and microbe-mediated effects of micronutrients. Recently, this model has been used to gain insight into the relationship between micronutrients, physiology, and metabolism. In particular, two B-type vitamins, vitamin B12 and folate, have been studied in detail. Here we review how C. elegans and its bacterial diet provide a powerful interspecies systems biology model that facilitates the precise delineation of micronutrient effects and the mechanisms involved.
饮食中需要少量的微量营养素来发挥关键的代谢作用，以进行生物量和能量的产生。人类可直接从饮食中获取微量营养素，也可从代谢其他营养素的肠道微生物群中获取。线虫秀丽隐杆线虫及其细菌食物提供了一个相对简单且易于进行基因研究的模型，用于研究微量营养素的直接作用和微生物介导的作用。最近，该模型已被用于深入了解微量营养素、生理学和新陈代谢之间的关系。特别是，两种B族维生素，即维生素B12和叶酸，已得到详细研究。在此，我们综述秀丽隐杆线虫及其细菌食物如何提供一个强大的种间系统生物学模型，有助于精确描述微量营养素的作用及其涉及的机制。
