Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, 201306, U.P., India.
Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, 201306, U.P., India.
Microbiol Res. 2018 Oct;215:102-113. doi: 10.1016/j.micres.2018.06.012. Epub 2018 Jun 25.
Caenorhabditis elegans is a model organism for the study of different molecular, biochemical, microbial and immunity-related mechanisms. In its natural habitat, C. elegans survives by feeding microorganisms (mainly bacteria), though majorly on Escherichia coli OP50 when grown in the laboratory. Numerous bacteria are shown to influence the lifespan, behavioural responses and innate immunity of C. elegans. The secondary metabolites produced by bacteria have shown to play key role in C. elegans longevity. This behaviour provides insights for potential development of new strategies for the treatment of diseases in other species, including humans. This review explains the concept of C. elegans microbiome, different mechanisms employed in its longevity and resistance against bacterial pathogens and the effects of various bacteria (both beneficial and harmful) as well as their products on the life cycle of C. elegans.
秀丽隐杆线虫是研究不同分子、生化、微生物和免疫相关机制的模式生物。在其自然栖息地，秀丽隐杆线虫通过摄食微生物（主要是细菌）生存，尽管在实验室中主要以大肠杆菌 OP50 为食。大量细菌被证明会影响秀丽隐杆线虫的寿命、行为反应和先天免疫。细菌产生的次生代谢物被证明在秀丽隐杆线虫的长寿中起着关键作用。这种行为为潜在的发展提供了新的策略，用于治疗包括人类在内的其他物种的疾病。本文综述了秀丽隐杆线虫微生物组的概念、其长寿和抵抗细菌病原体的不同机制，以及各种细菌（有益和有害）及其产物对秀丽隐杆线虫生命周期的影响。
