Spertzel R O
National Institutes of Health, Bethesda, MD 20892.
Antiviral Res. 1989 Dec;12(5-6):223-30. doi: 10.1016/0166-3542(89)90050-8.
The search for a model of HIV infection continues. While much of the initial work focussed on animal models of AIDS, more recent efforts have sought animal models of HIV infection in which one or more signs of AIDS may be reproduced. Most initial small animal modelling efforts were negative and many such efforts remain unpublished. In 1988, the Public Health Service (PHS) AIDS Animal Model Committee conducted a survey among PHS agencies to identify published and unpublished data on animal models of HIV. To date, the chimpanzee is the only animal to be reliably infected with HIV albeit without development of signs and symptoms normally associated with human AIDS. One recent study has shown the gibbon to be similarly susceptible to infection with HIV. Mice carrying a chimera of elements of the human immune system have been shown to support the growth of HIV and F1 progeny of transgenic mice containing intact copies of HIV proviral DNA, have developed a disease that resembles some aspects of human AIDS. Rabbits, baboons and rhesus monkeys have also been shown to be infected under certain conditions and/or with selected strains of HIV but again without the development of AIDS symptomatology. This report briefly summarizes published and available unpublished data on these efforts to develop an animal model of HIV infection.
对艾滋病毒感染模型的探索仍在继续。虽然最初的许多工作集中在艾滋病的动物模型上，但最近的努力则是寻找能够重现一种或多种艾滋病症状的艾滋病毒感染动物模型。大多数早期的小型动物建模工作都没有成功，而且许多此类工作仍未发表。1988年，公共卫生服务（PHS）艾滋病动物模型委员会在PHS各机构中进行了一项调查，以确定有关艾滋病毒动物模型的已发表和未发表数据。迄今为止，黑猩猩是唯一能被艾滋病毒可靠感染的动物，尽管它不会出现通常与人类艾滋病相关的体征和症状。最近的一项研究表明，长臂猿对艾滋病毒感染同样易感。携带人类免疫系统元件嵌合体的小鼠已被证明能支持艾滋病毒的生长，而含有完整艾滋病毒前病毒DNA拷贝的转基因小鼠的F1代，已出现了类似于人类艾滋病某些方面的疾病。兔子、狒狒和恒河猴也已被证明在某些条件下和/或感染某些艾滋病毒毒株时会被感染，但同样不会出现艾滋病症状。本报告简要总结了有关这些开发艾滋病毒感染动物模型工作的已发表和可得的未发表数据。
