Slykerman Rebecca F, Thompson John, Waldie Karen, Murphy Rinki, Wall Clare, Mitchell Edwin A
Starship Children's Hospital, Auckland District Health Board, Auckland, New Zealand.
Acta Paediatr. 2015 Jan;104(1):68-74. doi: 10.1111/apa.12787. Epub 2014 Oct 21.
Maternal stress during pregnancy has been associated with negative outcomes in children. We examined the risk factors for symptoms of depression in 11-year-old children, including the interaction between birthweight and other variables.
We collected maternal, obstetric and demographic information from birth through to the age of 11. Approximately, half of the 609 children were born small-for-gestational-age (SGA). Information collected at 3.5 and 7 years of age included intelligence testing and parent-reported behavioural and emotional development. At 11 years of age, the children completed the Center for Epidemiological Studies Depression Scale for Children. Multivariable logistic regression analysis examined the relationship between self-reported symptoms of moderate to severe depression at the age of 11 and explanatory variables.
Symptoms of moderate to severe depression were related to increasing maternal stress during pregnancy, young maternal age, lower intelligence test scores at 7-years-old and being bullied at school in the previous 6 months. There was also a significant interaction between maternal stress in pregnancy and symptoms of depression in 11-year-old children born SGA.
Increasing maternal stress during pregnancy was associated with increased risk of symptoms of moderate to severe depression in 11-year-old children, especially those who were born SGA.
孕期母亲压力与儿童不良后果相关。我们研究了11岁儿童抑郁症状的风险因素，包括出生体重与其他变量之间的相互作用。
我们收集了从出生到11岁的母亲、产科和人口统计学信息。在609名儿童中，约一半为小于胎龄儿（SGA）。在3.5岁和7岁时收集的信息包括智力测试以及家长报告的行为和情感发育情况。11岁时，儿童完成了儿童流行病学研究中心抑郁量表。多变量逻辑回归分析研究了11岁时自我报告的中度至重度抑郁症状与解释变量之间的关系。
中度至重度抑郁症状与孕期母亲压力增加、母亲年龄较小、7岁时智力测试得分较低以及过去6个月在学校受欺负有关。孕期母亲压力与SGA出生的11岁儿童的抑郁症状之间也存在显著的相互作用。
孕期母亲压力增加与11岁儿童出现中度至重度抑郁症状的风险增加有关，尤其是那些SGA出生的儿童。
