Liu T H, Li D C, Gu C F, Ye S F
Chin Med J (Engl). 1989 Aug;102(8):630-8.
Carbamyl phosphate synthetase I (CPS1) is an initial enzyme of urea synthetase system. It exists exclusively in liver cells and epithelial cells of the small intestine. By immunocytochemistry, 70.5% of 88 surgically resected gastric carcinomas (42 advanced and 46 early gastric carcinomas) was found to be CPS1 immunoreaction positive, whereas all other carcinomas (of the esophagus, colon, pancreas, lung, breast, ovary, kidney, prostate and urinary bladder) tested were negative. CPS1 expression in gastric carcinoma was closely related to the types of mucin secreted by the carcinoma cells. Most carcinomas secreting sialomucin were CPS1 positive, yet those secreting sulfomucin or neutral mucin did not express CPS1. The types of intestinal metaplasia adjacent to the carcinoma correlated neither with CPS1 expression nor with the histological types of carcinoma. Owing to the fact that gastric carcinomas with CPS1 expression possess the characteristics of small intestinal epithelium, it is very likely that CPS1 can be used as a novel marker for gastric carcinoma originating from complete type intestinal metaplasia.
氨甲酰磷酸合成酶I（CPS1）是尿素合成酶系统的起始酶。它仅存在于肝细胞和小肠上皮细胞中。通过免疫细胞化学方法，在88例手术切除的胃癌（42例进展期胃癌和46例早期胃癌）中，发现70.5%的病例CPS1免疫反应呈阳性，而所检测的其他所有癌症（食管癌、结肠癌、胰腺癌、肺癌、乳腺癌、卵巢癌、肾癌、前列腺癌和膀胱癌）均为阴性。胃癌中CPS1的表达与癌细胞分泌的黏液类型密切相关。大多数分泌涎黏蛋白的癌症CPS1呈阳性，而分泌硫黏蛋白或中性黏液的癌症则不表达CPS1。癌旁肠化生的类型与CPS1表达及癌症的组织学类型均无关联。鉴于具有CPS1表达的胃癌具有小肠上皮的特征，CPS1很有可能可作为源自完全型肠化生的胃癌的一种新型标志物。
