缺氧缺血性脑损伤：未来潜在的治疗干预措施。
Hypoxic ischemic brain injury: Potential therapeutic interventions for the future.
作者信息
Muller Aaron J, Marks Jeremy D
机构信息
Department of Pediatrics, University of Chicago 900 East 57th Street Chicago IL 60637.
Department of Neurology, University of Chicago 900 East 57th Street Chicago IL 60637.
出版信息
Neoreviews. 2014 May 1;15(5):e177-e186. doi: 10.1542/neo.15-5-e177.
Abstract
Perinatal hypoxic-ischemic brain injury is a common problem with potentially devastating impact on neurodevelopmental outcomes. While therapeutic hypothermia, the first available treatment for this disease, reduces the risk of death or major neurodevelopmental disability, the risk of major neurologic morbidity following HI remains significant. Basic research has identified cellular mechanisms that mediate neuronal death. This article reviews the cellular processes induced that lead to brain injury following HI, and identify treatments currently under investigation for potential translation to clinical trials.
摘要
围产期缺氧缺血性脑损伤是一个常见问题，对神经发育结局可能产生毁灭性影响。虽然治疗性低温是该疾病的首个可用治疗方法，可降低死亡或严重神经发育残疾的风险，但缺氧缺血后严重神经功能障碍的风险仍然很高。基础研究已经确定了介导神经元死亡的细胞机制。本文综述了缺氧缺血后导致脑损伤的细胞过程，并确定了目前正在研究的有望转化为临床试验的治疗方法。
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