South East Wales Trials Unit (SEWTU), Cardiff University, Cardiff, UK.
J Sleep Res. 2015 Feb;24(1):19-23. doi: 10.1111/jsr.12200. Epub 2014 Sep 2.
Sleeping difficulties in childhood have been associated with an increased risk of depression in adult life, but existing studies have not accounted for comorbid maternal sleeping difficulties and depression. This study aimed to determine the association between childhood sleeping difficulties and depression in adulthood after adjusting for the potential confounding influences of maternal depression and sleeping difficulties. Data from the British Cohort Study 1970, a prospective birth cohort with 30 years of follow-up (1975-2005) were used. At 5 years of age, 7437 parents of participants recorded information on whether their child had sleeping difficulties, the frequency of bed-wetting, nightmares, maternal depression and sleep difficulties. At 34 years of age, participants reported whether or not they had received medical treatment for depression in the past year. Parental reports of severe sleeping difficulties at 5 years were associated with an increased risk of depression at age 34 years [odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.2, 3.2] whereas moderate sleeping difficulties were not (OR = 1.1, 95% CI = 0.9, 1.3). In conclusion, severe sleeping problems in childhood may be associated with increased susceptibility to depression in adult life.
儿童睡眠困难与成年后患抑郁症的风险增加有关，但现有研究并未考虑到同时存在的母婴睡眠困难和抑郁共病问题。本研究旨在确定在调整了潜在的混杂因素（包括母亲抑郁和睡眠困难）的情况下，儿童期睡眠困难与成年期抑郁之间的关联。该研究的数据来自于英国队列研究 1970 年，这是一个具有 30 年随访期（1975-2005 年）的前瞻性出生队列。在 5 岁时，7437 名参与者的父母记录了他们的孩子是否存在睡眠困难、尿床频率、梦魇、母亲抑郁和睡眠困难等信息。在 34 岁时，参与者报告了他们在过去一年中是否因抑郁接受过治疗。父母报告的 5 岁时严重睡眠困难与 34 岁时患抑郁症的风险增加有关（比值比（OR）=1.9，95%置信区间（CI）=1.2，3.2），而中度睡眠困难则没有（OR=1.1，95%CI=0.9，1.3）。综上所述，儿童期严重的睡眠问题可能与成年后患抑郁症的易感性增加有关。
