埃塞俄比亚德西健康研究实验室尿路感染细菌分离株的患病率及抗菌谱
Prevalence and antibiogram of bacterial isolates from urinary tract infections at Dessie Health Research Laboratory, Ethiopia.
作者信息
Kibret Mulugeta, Abera Bayeh
机构信息
Department of Biology, Science College, Bahir Dar University, P.O.Box 79 Bahir Dar, Ethiopia.
Department of Microbiology, Parasitology and Immunology, College of Medicine and Health Sciences, Bahir Dar University, P.O.Box 79, Bahir Dar, Ethiopia.
出版信息
Asian Pac J Trop Biomed. 2014 Feb;4(2):164-8. doi: 10.1016/S2221-1691(14)60226-4.
OBJECTIVE
To determine the prevalence and antimicrobial susceptibility of bacteria from suspected urinary tract infections.
METHODS
A retrospective analysis of bacterial pathogens and their antimicrobial susceptibility was done on urine samples at Dessie Regional Laboratory in the period 2003 to 2010. Antimicrobial susceptibility tests were done using disc diffusion technique as per the standard of Kirby-Bauer method.
RESULTS
The male to female ratio of the patients was 1:1.96. Of the total 1 404 samples, 319 (22.7%) were culture positive. Escherichia coli was the dominant isolate (63.6%) followed by Klebsiella spp. (8.5%) and Proteus spp. (8.2%). The overall resistance rates to erythromycin, amoxycillin, and tetracycline were 85.6%, 88.9% and 76.7%, respectively. The three most frequently isolated bacteria had resistance rates of 80.1%-90.0% to, amoxycillin, and tetracycline and sensitivity rates of 0 to 25% to nitrofurantoin, ciprofloxacin and gentamicin. Antibiogram of isolates showed that 152 (47.85%) isolates were resistance to two and more antimicrobials.
CONCLUSIONS
In the study area resistance rates to erythromycin, amoxycillin and tetracycline were high. Since most isolates were sensitive to nitrofurantoin and gentamicin, they are considered as appropriate antimicrobials for empirical treatment urinary tract infections.
目的
确定疑似尿路感染细菌的患病率及抗菌药敏情况。
方法
对2003年至2010年期间德西地区实验室的尿液样本进行细菌病原体及其抗菌药敏的回顾性分析。按照 Kirby-Bauer 方法的标准，采用纸片扩散法进行抗菌药敏试验。
结果
患者男女比例为1:1.96。在总共1404份样本中，319份（22.7%）培养呈阳性。大肠埃希菌是主要分离菌株（63.6%），其次是克雷伯菌属（8.5%）和变形杆菌属（8.2%）。对红霉素、阿莫西林和四环素的总体耐药率分别为85.6%、88.9%和76.7%。三种最常分离的细菌对阿莫西林和四环素的耐药率为80.1%-90.0%，对呋喃妥因、环丙沙星和庆大霉素的敏感率为0至25%。分离菌株的抗菌谱显示，152份（47.85%）菌株对两种及以上抗菌药物耐药。
结论
在研究区域，对红霉素、阿莫西林和四环素的耐药率较高。由于大多数分离菌株对呋喃妥因和庆大霉素敏感，它们被认为是用于尿路感染经验性治疗的合适抗菌药物。
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