Tahir Bawlah, Tayib Niman, Ahmed Abdi Hassen, Tolossa Daniel, Mekuria Surafel, Barsenga Shamil, Muse Kader, Tesfaye Sara, Tesfaye Addisu, Getu Fasil, Roble Abdurahman Kedir, Mahdi Abdirizak, Osman Mahad
Medical Laboratory Science, School of Medicine, Institute of Health Science, Jigjiga University, Jigjiga, Ethiopia.
Midwifery Department, School of Medicine, Institute of Health Science, Jigjiga University, Jigjiga, Ethiopia.
BMC Infect Dis. 2025 May 31;25(1):777. doi: 10.1186/s12879-025-11122-y.
Diabetic Mellitus (DM) is a chronic condition characterized with higher blood glucose due to lack of insulin production, or the body cannot effectively use insulin. Bacterial urinary tract infections (UTIs) remains one of the common public health crises in diabetic patients worldwide. Diabetic patients are at a high risk of developing UTIs. In addition, the emergence of rapid drug resistance nowadays poses a great public health threat in management of bacterial UTIs in diabetic patients worldwide.
To assess the prevalence, bacterial profile, antimicrobial susceptibility pattern and associated risk factors of bacterial UTI among Diabetic patients at Jigjiga University Sheik Hasan Yabare Comprehensive Specialized Hospital, Jigjiga Eastern Ethiopia from February 20, to April 30, 2024.
Institution-based cross-sectional study was conducted from February 20, to April 30, 2024. Total of 220 study participants were recruited. Clean catch mid-stream urine was collected and was inoculated onto MacConkey agar and Blood agar. Bacterial identification was carried out based on standard protocol. Antibiotic susceptibility testing was done by Kirby Baurer disc diffusion method. The data were entered into Epi-data version 4.6, exported to and analyzed in SPSS version 25. Bivariate and multivariable logistic regression analysis was performed to measure the association. P-value ≤ 0.05 was considered statistically significant.
The overall prevalence of significant bacteriuria among Diabetic patients was 10.5% (23/220, 95%CI: 6.4 - 14.6%). Of these, 82.6% (19/23) were gram negative bacteria. E. coli was the most isolated uropathogens constituting 65.2% (15/23) followed by S. epidermis, 8.7% (2/23). Duration of DM, history of hypertension and being symptomatic for UTI at the present were statistically associated with significant bacteriuria. Gram negative uropathogens were highly susceptible to nitrofurantoin (94.7%), amikacin (84.2%) and tobramycin (68.4%). Gram positive isolates were 100% susceptible to nitrofurantoin and gentamicin. The overall proportion of Multi-drug resistance among the bacterial isolates was 60.9% (14/23, 95%CI; 54.5-67.3%).
An identification of higher rate Multi-drug resistant uropathogens necessitates proper care of antibiotic selection for prescription and enhancing microbiological testing coverage in the low-income settings.
糖尿病（DM）是一种慢性病，其特征是由于胰岛素分泌不足或身体无法有效利用胰岛素导致血糖升高。细菌性尿路感染（UTIs）仍然是全球糖尿病患者中常见的公共卫生危机之一。糖尿病患者发生UTIs的风险很高。此外，如今快速出现的耐药性对全球糖尿病患者细菌性UTIs的管理构成了巨大的公共卫生威胁。
评估2024年2月20日至4月30日在埃塞俄比亚东部吉吉加市吉吉加大学谢赫·哈桑·亚巴雷综合专科医院糖尿病患者中细菌性UTI的患病率、细菌谱、抗菌药物敏感性模式及相关危险因素。
于2024年2月20日至4月30日进行基于机构的横断面研究。共招募了220名研究参与者。收集清洁中段尿并接种于麦康凯琼脂和血琼脂上。根据标准方案进行细菌鉴定。采用 Kirby Baurer 纸片扩散法进行药敏试验。数据录入Epi-data 4.6版本，导出至SPSS 25版本进行分析。进行二元和多变量逻辑回归分析以衡量关联性。P值≤0.05被认为具有统计学意义。
糖尿病患者中显著菌尿的总体患病率为10.5%（23/220，95%CI：6.4 - 14.6%）。其中，82.6%（19/23）为革兰氏阴性菌。大肠埃希菌是最常见的尿路致病菌，占65.2%（15/23），其次是表皮葡萄球菌，占8.7%（2/23）。糖尿病病程、高血压病史以及目前有UTI症状与显著菌尿在统计学上相关。革兰氏阴性尿路致病菌对呋喃妥因（94.7%）、阿米卡星（84.2%）和妥布霉素（68.4%）高度敏感。革兰氏阳性分离株对呋喃妥因和庆大霉素100%敏感。细菌分离株中多重耐药的总体比例为60.9%（14/23，95%CI；54.5 - 67.3%）。
多药耐药尿路致病菌的高检出率表明在低收入环境中需要谨慎选择抗生素进行处方，并加强微生物检测覆盖范围。
