Hess Donavon J, Henry-Stanley Michelle J, Wells Carol L
Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, USA.
Antimicrob Agents Chemother. 2014 Nov;58(11):6970-3. doi: 10.1128/AAC.03672-14. Epub 2014 Sep 2.
Glycerol monolaurate (GML) is a natural surfactant with antimicrobial properties. At ∼0.3 mM, both GML and its component lauric acid were bactericidal for antibiotic-resistant Staphylococcus aureus biofilms. With the use of MICs of antibiotics obtained from planktonic cells, GML and lauric acid acted synergistically with gentamicin and streptomycin, but not ampicillin or vancomycin, to eliminate detectable viable biofilm bacteria. Images of GML-treated biofilms suggested that GML may facilitate antibiotic interaction with matrix-embedded bacteria.
甘油单月桂酸酯(GML)是一种具有抗菌特性的天然表面活性剂。在约0.3 mM浓度下,GML及其成分月桂酸对耐抗生素金黄色葡萄球菌生物膜均具有杀菌作用。利用从浮游细胞获得的抗生素最低抑菌浓度(MIC),GML和月桂酸与庆大霉素和链霉素协同作用,可消除可检测到的存活生物膜细菌,但与氨苄西林或万古霉素无协同作用。经GML处理的生物膜图像表明,GML可能有助于抗生素与包埋在基质中的细菌相互作用。