Tian Yongji, Wang Junmei, Ge Jin zhao, Ma Zhenyu, Ge Ming
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Childs Nerv Syst. 2015 Feb;31(2):317-23. doi: 10.1007/s00381-014-2536-y. Epub 2014 Sep 3.
Rosai-Dorfman disease (RDD) is a rare idiopathic, non-neoplastic histioproliferative disease. Central nervous system (CNS) manifestations are extremely rare. In this paper, we describe a 6-year-old boy with intracranial RDD mimicking multiple meningiomas both clinically and radiologically. We reviewed the literature to understand the clinical behaviour, clinicopathological features and treatment options.
A PubMed (US National Library of Medicine) search using the keywords 'Rosai-Dorfman disease' and 'central nervous system' was performed and citations were reviewed.
Eighty-five cases of RDD involving the CNS have been reported until date, and only 7 cases involved children. Of the 85 cases, 16 cases mimicked multiple meningiomas. Our case is the first to involve multiple lesions in a child under 14 years old.
After reviewing the literature, we concluded that RDD should be considered as a differential diagnosis for lesions mimicking multiple meningiomas, especially in children. Resection of the intracranial lesion is the most effective treatment, and a definitive diagnosis should be based on histopathologic and immunocytochemical examinations.
罗萨伊-多夫曼病（RDD）是一种罕见的特发性非肿瘤性组织细胞增生性疾病。中枢神经系统（CNS）表现极为罕见。在本文中，我们描述了一名6岁男孩，其颅内RDD在临床和放射学上均酷似多发脑膜瘤。我们回顾了文献以了解其临床行为、临床病理特征及治疗选择。
利用关键词“罗萨伊-多夫曼病”和“中枢神经系统”在PubMed（美国国立医学图书馆）进行检索，并对文献引用进行回顾。
截至目前，已报道85例累及中枢神经系统的RDD病例，其中仅7例为儿童患者。在这85例病例中，16例酷似多发脑膜瘤。我们的病例是首例14岁以下儿童出现多发病灶的情况。
在回顾文献后，我们得出结论，RDD应被视为酷似多发脑膜瘤的病变的鉴别诊断之一，尤其是在儿童中。颅内病变切除是最有效的治疗方法，确诊应基于组织病理学和免疫细胞化学检查。
