Sebastian Nadia T, Collins Kathleen L
Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Expert Rev Anti Infect Ther. 2014 Oct;12(10):1187-201. doi: 10.1586/14787210.2014.956094. Epub 2014 Sep 4.
Current therapy for HIV effectively suppresses viral replication and prolongs life, but the infection persists due, at least in part, to latent infection of long-lived cells. One favored strategy toward a cure targets latent virus in resting memory CD4(+) T cells by stimulating viral production. However, the existence of an additional reservoir in bone marrow hematopoietic progenitor cells has been detected in some treated HIV-infected people. This review describes approaches investigators have used to reactivate latent proviral genomes in resting CD4(+) T cells and hematopoietic progenitor cells. In addition, the authors review approaches for clearance of these reservoirs along with other important topics related to HIV eradication.
目前的艾滋病治疗方法能有效抑制病毒复制并延长生命，但感染仍会持续，至少部分原因是长寿细胞的潜伏感染。一种备受青睐的治愈策略是通过刺激病毒产生来靶向静息记忆CD4(+) T细胞中的潜伏病毒。然而，在一些接受治疗的HIV感染者中，已检测到骨髓造血祖细胞中存在额外的病毒储存库。这篇综述描述了研究人员用于重新激活静息CD4(+) T细胞和造血祖细胞中潜伏前病毒基因组的方法。此外，作者还综述了清除这些病毒储存库的方法以及与根除HIV相关的其他重要主题。
