4型副猪嗜血杆菌强毒株和无毒株的全基因组关联研究
Genome-Wide Association Studies of Virulent and Avirulent Haemophilus parasuis Serotype 4 Strains.
作者信息
Lawrence Paulraj K, Wiener Brittanny L, Kolander-Bremer Tammy, Bey Russell F, Stine Douglas L, Kittichotirat Weerayuth, Bumgarner Roger E
机构信息
Newport Laboratories, Inc., Worthington, Minnesota, USA plawrence@newportlabs.
Newport Laboratories, Inc., Worthington, Minnesota, USA.
出版信息
Genome Announc. 2014 Sep 4;2(5):e00884-14. doi: 10.1128/genomeA.00884-14.
Haemophilus parasuis is a normal commensal of the upper respiratory tract of healthy pigs. However, in conjunction with stress and/or viral infections, or in immunocompromised animals, H. parasuis can transform into a pathogen causing Glasser's disease, which is typically characterized by fibrinous polyserositis, polyarthritis, meningitis, and sometimes acute pneumonia and septicemia. H. parasuis serotype 5 is highly virulent and more frequently isolated from respiratory and systemic infection in pigs. Recently Newport Laboratories isolated highly virulent H. parasuis serotype 4 strains from the tissues of diseased pigs. This study was undertaken to identify the genes responsible for H. parasuis serotype 4 virulence. To achieve this objective we performed genome-wide association studies (GWAS) across two virulent and three avirulent H. parasuis serotype 4 strains.
副猪嗜血杆菌是健康猪上呼吸道的一种正常共生菌。然而，在应激和/或病毒感染的情况下，或者在免疫功能低下的动物中，副猪嗜血杆菌可转变为病原体，引发格氏病，该病的典型特征是纤维素性多浆膜炎、多关节炎、脑膜炎，有时还伴有急性肺炎和败血症。副猪嗜血杆菌血清型5具有高度致病性，且更频繁地从猪的呼吸道和全身感染中分离出来。最近，纽波特实验室从患病猪的组织中分离出了高致病性的副猪嗜血杆菌血清型4菌株。本研究旨在鉴定副猪嗜血杆菌血清型4毒力相关基因。为实现这一目标，我们对两株有毒力和三株无毒力的副猪嗜血杆菌血清型4菌株进行了全基因组关联研究（GWAS）。
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