产前接触海洛因、美沙酮及其他阿片类物质的婴儿早期发育缺陷的识别。
Identification of early developmental deficits in infants with prenatal heroin, methadone, and other opioid exposure.
作者信息
Beckwith Anna Malia, Burke Sharon A
机构信息
Children's Specialized Hospital, Rutgers-Robert Wood Johnson Medical School, Mountainside, NJ, USA
Children's Specialized Hospital, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
出版信息
Clin Pediatr (Phila). 2015 Apr;54(4):328-35. doi: 10.1177/0009922814549545. Epub 2014 Sep 4.
OBJECTIVE
Study aims to examine development in infants following prenatal heroin, methadone, and opioid exposure, which adversely affects central and autonomic nervous systems. Abrupt discontinuation results in neurologic and behavioral findings as Neonatal Abstinence Syndrome (NAS).
METHOD
Following NAS treatment, 28 infants (mean age 55 days [range 21-98 days], 57% male) were assessed using Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) Cognitive, Language, and Motor subscales. Outcomes were compared with a historical control.
RESULTS
Mean Language and Cognition scores were significantly lower (P < .001) in the NAS group. Distributions of scores for Language (P < .001) and Cognition (P = .022) were also significantly different between NAS and historical control groups.
CONCLUSION
Prenatal heroin, methadone, and other opioid exposure is associated with weaknesses in language and cognition. This information has important public health implications, drawing attention to an otherwise healthy infant population which may benefit from early intervention services.
目的
研究旨在检查产前接触海洛因、美沙酮和阿片类药物的婴儿的发育情况，这些药物会对中枢和自主神经系统产生不利影响。突然停药会导致出现如新生儿戒断综合征（NAS）等神经和行为表现。
方法
在对NAS进行治疗后，使用贝利婴幼儿发展量表第三版（Bayley-III）的认知、语言和运动分量表对28名婴儿（平均年龄55天[范围21 - 98天]，57%为男性）进行评估。将结果与一个历史对照组进行比较。
结果
NAS组的平均语言和认知得分显著更低（P < .001）。NAS组与历史对照组之间语言（P < .001）和认知（P = .022）得分的分布也存在显著差异。
结论
产前接触海洛因、美沙酮和其他阿片类药物与语言和认知方面的弱点有关。这一信息具有重要的公共卫生意义，使人们关注到这样一个原本健康的婴儿群体，他们可能会从早期干预服务中受益。
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