Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands; Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands; Eindhoven Cancer Registry, Comprehensive Cancer Center South, Eindhoven, The Netherlands.
J Am Acad Dermatol. 2014 Nov;71(5):896-903. doi: 10.1016/j.jaad.2014.07.003. Epub 2014 Sep 1.
Keratinocyte cancer is the most common cancer among Caucasians.
We sought to study time trends of the burden of disease attributable to keratinocyte cancer in The Netherlands.
Data of all patients with newly diagnosed keratinocyte cancer (ie, squamous cell carcinoma and basal cell carcinoma) were obtained from the population-based Netherlands Cancer Registry and the Eindhoven Cancer Registry (1989-2008). Population structure, mortality data, and life expectancy data were extracted from Statistics Netherlands. The disability-adjusted life-years (DALY) was the sum of the years of life lived with disability and the years of life lost.
The world standardized rate of keratinocyte cancer has doubled and was 103 and 94 per 100,000 person-years for males and females in 2004 to 2008, respectively. DALYs as a result of basal cell carcinoma increased by 124% and DALYs as a result of squamous cell carcinoma increased by 66% from 1989 to 1993. Keratinocyte cancer accounted for a total loss of 19,913 DALYs (15,369 years of life lived with disability and 4544 years of life lost) between 2004 and 2008.
Only the first keratinocyte cancer was included in this study.
Keratinocyte cancer is a large burden to the Dutch society. Because incidence rates of keratinocyte cancer continue to increase, the management becomes even more challenging.
角化细胞癌是白种人中最常见的癌症。
我们旨在研究荷兰角化细胞癌疾病负担的时间趋势。
所有新诊断为角化细胞癌（即鳞状细胞癌和基底细胞癌）患者的数据均来自基于人群的荷兰癌症登记处和埃因霍温癌症登记处（1989-2008 年）。人口结构、死亡率数据和预期寿命数据均从荷兰统计局提取。残疾调整生命年（DALY）是生命残疾年数和生命损失年数的总和。
2004 年至 2008 年，男性和女性的世界标准化角化细胞癌发病率分别翻了一番，分别为 103 和 94/10 万人口年。基底细胞癌导致的 DALY 增加了 124%，鳞状细胞癌导致的 DALY 增加了 66%，从 1989 年至 1993 年。2004 年至 2008 年间，角化细胞癌导致了总共 19913 个 DALY 的损失（15369 年的生命残疾和 4544 年的生命损失）。
本研究仅包括首次诊断的角化细胞癌。
角化细胞癌对荷兰社会是一个重大负担。由于角化细胞癌的发病率持续上升，管理变得更加具有挑战性。
