Human Resource Development Department, CSIR-Central Food Technological Research Institute, Mysore, 570 020 India.
J Food Sci Technol. 2014 Sep;51(9):1965-73. doi: 10.1007/s13197-013-1210-9. Epub 2014 Feb 2.
Tamarindus indica seed coat was extracted with methanol, acetone and water and screened for DPPH radical scavenging activities. Methanol extract showed higher activity than other extracts. Treatment of albino rats (Wistar strain) with CCl4 at 1.25 mL/kg of body weight decreased superoxide dismutase (55 %), catalase (73 %) and peroxidase (78 %), while lipid peroxidation increased nearly 2.5 fold in liver. Pretreatment of rats with methanol extract of T. Indica seed coat (TSCE) at 50 mg/kg (as tannic acid equivalents) followed by CCl4 treatment, caused restoration of superoxide dismutase, catalase and lipid peroxidation to values close to control while peroxidase was restored to 67 % of the control. Histopathological studies of liver of different groups supported the protective effects of TSCE by restoring the hepatic architecture. These studies could be further extended to exploit its possible application for the preservation of food products as well as a health supplement and neutraceutical.
罗望子种皮用甲醇、丙酮和水提取，并筛选出对 DPPH 自由基清除活性。甲醇提取物的活性高于其他提取物。用 1.25 毫升/千克体重的 CCl4 处理白化大鼠（Wistar 品系），超氧化物歧化酶（55%）、过氧化氢酶（73%）和过氧化物酶（78%）降低，而肝脏中的脂质过氧化增加近 2.5 倍。用罗望子种皮甲醇提取物（TSCE）预处理大鼠，剂量为 50 毫克/千克（以鞣酸当量计），然后用 CCl4 处理，可使超氧化物歧化酶、过氧化氢酶和脂质过氧化恢复到接近对照的值，而过氧化物酶则恢复到对照值的 67%。不同组肝脏的组织病理学研究支持 TSCE 的保护作用，可恢复肝结构。这些研究可以进一步扩展，以利用其在食品保存、保健品和营养保健品方面的潜在应用。
