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[五种人骨髓瘤细胞系的建立与鉴定]

[Establishment and characterization of five human myeloma cell lines].

作者信息

Ohtsuki T, Yawata Y, Namba M

机构信息

Department of Medicine, Kawasaki Medical School, Kurashiki, Japan.

出版信息

Hum Cell. 1989 Sep;2(3):297-303.

PMID:2519219
Abstract

Since 1980 five human myeloma cell lines, KMM-1, KMS-5, KMS-11, KMS-12-PE and KMS-12-BM, have been established in Kawasaki Medical School. Histologically, all the cell lines resembled plasma cells and were EBNA negative. KMM-1, KMS-11, KMS-12-PE and KMS-12-BM reacted with PCA-1, while KMM-1, KMS-12-PE and KMS-12-BM with CD38. KMM-1 and KMS-11 secreted immunoglobulins into culture medium. Karyologically, all the cell lines were abnormal. Only KMS-5 was tumorigenic when transplanted subcutaneously into nude mice.

摘要

自1980年以来，川崎医科大学已建立了5种人骨髓瘤细胞系，即KMM-1、KMS-5、KMS-11、KMS-12-PE和KMS-12-BM。从组织学上看，所有细胞系均类似浆细胞，且EBNA呈阴性。KMM-1、KMS-11、KMS-12-PE和KMS-12-BM与PCA-1反应，而KMM-1、KMS-12-PE和KMS-12-BM与CD38反应。KMM-1和KMS-11向培养基中分泌免疫球蛋白。从染色体学上看，所有细胞系均异常。只有KMS-5皮下移植到裸鼠体内时具有致瘤性。

相似文献

1
[Establishment and characterization of five human myeloma cell lines].[五种人骨髓瘤细胞系的建立与鉴定]
Hum Cell. 1989 Sep;2(3):297-303.
2
Establishment of five human myeloma cell lines.五种人骨髓瘤细胞系的建立。
In Vitro Cell Dev Biol. 1989 Aug;25(8):723-9. doi: 10.1007/BF02623725.
3
Cellular biological differences between human myeloma cell lines KMS-12-PE and KMS-12-BM established from a single patient.从一名患者身上建立的人骨髓瘤细胞系KMS-12-PE和KMS-12-BM之间的细胞生物学差异。
Int J Hematol. 2000 Aug;72(2):216-22.
4
Cell growth kinetics of cultured human myeloma cell lines, KMM-1 and KMS-5.培养的人骨髓瘤细胞系KMM-1和KMS-5的细胞生长动力学
Nihon Ketsueki Gakkai Zasshi. 1988 Sep;51(6):1052-8.
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Two human myeloma cell lines, amylase-producing KMS-12-PE and amylase-non-producing KMS-12-BM, were established from a patient, having the same chromosome marker, t(11;14)(q13;q32).两种人骨髓瘤细胞系，产淀粉酶的KMS-12-PE和不产淀粉酶的KMS-12-BM，是从一名患者体内建立的，它们具有相同的染色体标记，即t(11;14)(q13;q32)。
Br J Haematol. 1989 Oct;73(2):199-204. doi: 10.1111/j.1365-2141.1989.tb00252.x.
6
[Establishment and characterization of human esophageal carcinoma cell lines--especially the role of the serum-free culture].人食管癌细胞系的建立与鉴定——尤其是无血清培养的作用
Nihon Geka Gakkai Zasshi. 1991 Nov;92(11):1563-70.
7
Establishment of a new human myeloma cell line, KMS-18, having t(4;14)(p16.3;q32.3) derived from a case phenotypically transformed from Ig A-lambda to BJP-lambda, and associated with hyperammonemia.
Int J Oncol. 1998 Mar;12(3):545-52. doi: 10.3892/ijo.12.3.545.
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Establishment of CD7+ human myeloma sister cell lines, KMS-21-PE and KMS-21-BM, carrying t(11;14) and t(8;14).
Leuk Lymphoma. 2001 Aug;42(4):761-74. doi: 10.3109/10428190109099339.
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[Establishment and characterization of a human scirrhus type gastric cancer cell line, GCIY, producing CA19-9].[人黏液腺癌型胃癌细胞系GCIY的建立及其产生CA19-9的特性研究]
Hum Cell. 1991 Mar;4(1):71-5.
10
Effect of the nitrosourea anti-tumor chemotherapeutical agent MCNU on five human myeloma cell lines.亚硝基脲抗肿瘤化疗药物MCNU对五种人骨髓瘤细胞系的作用。
Oncol Rep. 1998 Jul-Aug;5(4):827-32. doi: 10.3892/or.5.4.827.

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