乳腺癌各亚型中淋巴结状态的预后价值。

The prognostic value of lymph node status among breast cancer subtypes.

作者信息

Liao Guo-Shiou, Chou Yu-Ching, Hsu Huan-Ming, Dai Ming-Shen, Yu Jyh-Cherng

机构信息

Division of General Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

School of Public Health, National Defense Medical Center, Taipei, Taiwan.

出版信息

Am J Surg. 2015 Apr;209(4):717-24. doi: 10.1016/j.amjsurg.2014.05.029. Epub 2014 Aug 5.

DOI:10.1016/j.amjsurg.2014.05.029

PMID:25192588

Abstract

BACKGROUND

Breast cancer subtypes (BCSs) are predictive of responses to specific therapies and of prognostic value for clinical outcomes. This study aimed to evaluate the relative 5-year overall survival (OS) and recurrence-free survival rates (RFS) based on lymph node (LN) status among BCSs.

METHODS

Medical records of 1,399 breast cancer patients treated from 2006 to 2011 were retrospectively reviewed. Pathologic findings, type of treatment, and OS and RFS were evaluated for 5 molecular subtypes.

RESULTS

Luminal A cancers accounted for 40.9% of the total, luminal B 21.5%, luminal human epidermal growth factor receptor 2 (HER2) 24.8%, HER2 6.9%, and triple negative 5.9%, of which 30% (n = 395) were LN positive. Analysis of patient characteristics showed significant differences among BCSs in age, tumor size, LN status, chemotherapy, and endocrine therapy. Adjustments for age and tumor size revealed significant differences in OS according to the nodal status in luminal A, luminal B, and luminal HER2 subtypes, and with RFS in the luminal B and luminal HER2 subtypes.

CONCLUSION

LN status in BCS presents an important prognostic factor of OS and RFS.

摘要

背景

乳腺癌亚型（BCSs）可预测对特定治疗的反应以及临床结局的预后价值。本研究旨在评估基于BCSs中淋巴结（LN）状态的相对5年总生存率（OS）和无复发生存率（RFS）。

方法

回顾性分析2006年至2011年接受治疗的1399例乳腺癌患者的病历。对5种分子亚型的病理结果、治疗类型以及OS和RFS进行评估。

结果

管腔A型癌症占总数的40.9%，管腔B型占21.5%，管腔人表皮生长因子受体2（HER2）型占24.8%，HER2型占6.9%，三阴性占5.9%，其中30%（n = 395）为LN阳性。患者特征分析显示，BCSs在年龄、肿瘤大小、LN状态、化疗和内分泌治疗方面存在显著差异。对年龄和肿瘤大小进行调整后发现，管腔A型、管腔B型和管腔HER2亚型的OS根据淋巴结状态存在显著差异，管腔B型和管腔HER2亚型的RFS也存在显著差异。