成功实施了单肺移植治疗多中心型Castleman 病。

Successful single-lung transplantation for multicentric Castleman disease.

机构信息

Department of Thoracic Surgery, Kyoto University, Kyoto, Japan.

Department of Diagnostic Pathology, Kyoto University, Kyoto, Japan; Department of Diagnostic Radiology, Kyoto University, Kyoto, Japan.

出版信息

Ann Thorac Surg. 2014 Sep;98(3):e63-5. doi: 10.1016/j.athoracsur.2014.06.074.

DOI:10.1016/j.athoracsur.2014.06.074

PMID:25193223

Abstract

We report a rare case of multicentric Castleman disease treated successfully with single-lung transplantation. A 12-year-old patient developed increasing dyspnea. Elevated serum interleukin-6 (177.0 pg/mL) and immunoglobulin G (IgG; 13,900 mg/dL) levels were observed. Steroid therapy was effective but the respiratory condition gradually deteriorated. He underwent single-lung transplantation at 36 years of age. Preoperative interleukin-6 and IgG levels were 0.3 pg/mL and 5,260 mg/dL, respectively. After 6 months he is alive without symptoms. Postoperative IgG levels were restored to normal limits (1,624 mg/dL) and interleukin-6 levels remained within normal limits (1.4 pg/mL). Overinflation of the native left lung also improved.

摘要

我们报告了一例成功接受单肺移植治疗的多中心 Castleman 病罕见病例。一名 12 岁患者出现进行性呼吸困难，检测到血清白细胞介素-6（177.0 pg/mL）和免疫球蛋白 G（IgG；13900 mg/dL）水平升高。类固醇治疗有效，但呼吸状况逐渐恶化。他在 36 岁时接受了单肺移植。术前白细胞介素-6和 IgG 水平分别为 0.3 pg/mL 和 5260 mg/dL。术后 6 个月，他无任何症状地存活。术后 IgG 水平恢复正常范围（1624 mg/dL），白细胞介素-6 水平也保持在正常范围内（1.4 pg/mL）。左肺过度充气也得到改善。