Kirkbride James B
Sir Henry Dale Fellow, Division of Psychiatry, University College London, 2nd Floor Charles Bell House, 67-73 Riding House Street, London, W1W 7EJ, UK,
Soc Psychiatry Psychiatr Epidemiol. 2014 Oct;49(10):1531-4. doi: 10.1007/s00127-014-0961-6. Epub 2014 Sep 6.
In this commentary I review the recent paper by Iyegbe et al. on "The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research". I discuss how the paper advances our knowledge of polygenic risk scores for use, amongst others, in gene-environment interaction studies and the opportunities and challenges such approaches will bring to our understanding of the epidemiology of psychotic disorders, including schizophrenia.
在这篇评论中，我回顾了伊耶贝等人最近发表的关于“精神分裂症新出现的分子结构、多基因风险评分及其对基因-环境相互作用研究的临床意义”的论文。我讨论了该论文如何推进我们对多基因风险评分的认识，这些评分可用于基因-环境相互作用研究等，以及此类方法将给我们理解包括精神分裂症在内的精神障碍流行病学带来的机遇和挑战。
