Laboratory of Molecular Microbiology, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.
Laboratory of Molecular Microbiology, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.
Infect Genet Evol. 2014 Dec;28:11-4. doi: 10.1016/j.meegid.2014.08.026. Epub 2014 Sep 2.
Whole genome sequencing of Novosibirsk human bocavirus (HBoV) isolates has detected an isolate that emerged via recombination between HBoV3 and HBoV4 genotypes. The recombination site is located between regions with abnormally low and abnormally high GC contents in the genome. This site is a bocavirus recombination hotspot and coincides with one of two parvovirus recombination hotspots. The Novosibirsk recombinant isolate, which is similar to a previously studied isolate from Thailand, utilizes the strategy of borrowing ORF3, which encodes structural proteins, of a rare genotype HBoV4. The role of recombination in HBoV evolution is discussed.
对新西伯利亚人类博卡病毒（HBoV）分离株的全基因组测序检测到一种分离株，该分离株是通过 HBoV3 和 HBoV4 基因型之间的重组产生的。重组位点位于基因组中 GC 含量异常低和异常高的区域之间。该位点是博卡病毒重组的热点，与两个细小病毒重组热点之一重合。新西伯利亚重组分离株与之前在泰国研究过的分离株相似，利用了借由罕见基因型 HBoV4 的 ORF3 编码结构蛋白的策略。本文讨论了重组在 HBoV 进化中的作用。
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