Padzys Guy Stéphane, Omouendze Linda Priscillia
Université des Sciences et Techniques de Masuku, BP: 943 Franceville, Gabon; Université de Lorraine, 34 cours Léopold 54000 Nancy, France.
Université des Sciences et Techniques de Masuku, BP: 943 Franceville, Gabon.
Int J Pediatr Otorhinolaryngol. 2014 Nov;78(11):1807-12. doi: 10.1016/j.ijporl.2014.07.020. Epub 2014 Jul 22.
We studied adaptation of diaphragm, oxygen consumption and carbon dioxide elimination to forced oral breathing (lasting for only 4 days) following reversible bilateral nasal obstruction performed on day 8 post-natal male rats.
Diaphragm myosin heavy chain (MHC) composition, oxygen consumption, carbon dioxide elimination and hormones level were analysed during nasal obstruction period.
Diaphragm muscle showed significant increases in adult isoforms (MHC 1, 2a) in oral breathing group versus control. Reversible nasal obstruction was associated with a decrease of oxygen consumption and carbon dioxide elimination. Nasal obstruction period was associated with reduced growth of the olfactory bulbs and an initial decrease in lung growth. One day after implementing nasal obstruction, basal corticosterone levels had increased (by over 1000). Oral breathing was also associated with a lower level of thyroid hormone.
We conclude that a 4 day nasal obstruction period in young rats leads to hormonal changes and to Diaphragm myosin heavy chain structural adaptation.
我们研究了在出生后第8天对雄性大鼠进行可逆性双侧鼻阻塞后，膈肌对强迫口腔呼吸（仅持续4天）的适应性、耗氧量和二氧化碳排出情况。
在鼻阻塞期间分析膈肌肌球蛋白重链（MHC）组成、耗氧量、二氧化碳排出和激素水平。
与对照组相比，口腔呼吸组的膈肌肌肉中成年亚型（MHC 1、2a）显著增加。可逆性鼻阻塞与耗氧量和二氧化碳排出的减少有关。鼻阻塞期与嗅球生长减少和肺生长初期下降有关。实施鼻阻塞一天后，基础皮质酮水平升高（超过1000）。口腔呼吸还与较低水平的甲状腺激素有关。
我们得出结论，幼鼠4天的鼻阻塞期会导致激素变化和膈肌肌球蛋白重链结构适应。
