EA 3450 DevAH, Université de Lorraine, 54505 Vandœuvre-lès-Nancy, France.
UMR 7039 CNRS, Université de Lorraine, 54505 Vandœuvre-lès-Nancy, France.
Physiol Behav. 2017 Aug 1;177:257-262. doi: 10.1016/j.physbeh.2017.05.007. Epub 2017 May 10.
Atmospheric CO concentrations increased significantly over the last century and continuing increases are expected to have significant effects on current ecosystems. This study evaluated the behavioural and physiological (hormone status, muscle structure) effects of prolonged CO exposure in young female Wistar rats exposed at 700ppm of CO during 6h a day for 15days. Prolonged CO exposure, though not continuous, produced significant disturbances in behaviour with an increase in drinking, grooming and resting, and a reduction in rearing, jumping-play and locomotor activity. Furthermore, CO exposure was accompanied by increased plasma levels of corticosterone, suggesting that prolonged exposure to CO was stressful. The muscular structure can also be modified also when respiratory working conditions change. The expression of myosin heavy chain was significantly affected in the diaphragm and oral respiratory muscles: Masseter Superficialis and Anterior Digastric. Modified behaviour and hormonal changes both appear to be at the origin of the observed muscular adaptation.
在过去的一个世纪中，大气 CO 浓度显著增加，预计持续增加将对当前的生态系统产生重大影响。本研究评估了在 700ppm CO 下每天暴露 6 小时持续 15 天的年轻雌性 Wistar 大鼠的行为和生理（激素状态、肌肉结构）变化。尽管不是连续的，但长时间的 CO 暴露会导致行为显著紊乱，表现为饮水、梳理和休息增加，而站立、跳跃玩耍和运动活动减少。此外，CO 暴露会导致血浆皮质酮水平升高，表明长时间暴露于 CO 会产生压力。当呼吸工作条件改变时，肌肉结构也会发生改变。膈肌和口腔呼吸肌（咬肌浅部和前二腹肌）中的肌球蛋白重链表达明显受到影响。观察到的肌肉适应性似乎源于行为和激素变化的改变。
