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迷走神经传入刺激可重置压力反射神经弧并抑制交感神经活动。

Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity.

作者信息

Saku Keita, Kishi Takuya, Sakamoto Kazuo, Hosokawa Kazuya, Sakamoto Takafumi, Murayama Yoshinori, Kakino Takamori, Ikeda Masataka, Ide Tomomi, Sunagawa Kenji

机构信息

Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

出版信息

Physiol Rep. 2014 Sep 4;2(9). doi: 10.14814/phy2.12136. Print 2014 Sep 1.

Abstract

It has been established that vagal nerve stimulation (VNS) benefits patients and/or animals with heart failure. However, the impact of VNS on sympathetic nerve activity (SNA) remains unknown. In this study, we investigated how vagal afferent stimulation (AVNS) impacts baroreflex control of SNA. In 12 anesthetized Sprague-Dawley rats, we controlled the pressure in isolated bilateral carotid sinuses (CSP), and measured splanchnic SNA and arterial pressure (AP). Under a constant CSP, increasing the voltage of AVNS dose dependently decreased SNA and AP. The averaged maximal inhibition of SNA was -28.0 ± 10.3%. To evaluate the dynamic impacts of AVNS on SNA, we performed random AVNS using binary white noise sequences, and identified the transfer function from AVNS to SNA and that from SNA to AP. We also identified transfer functions of the native baroreflex from CSP to SNA (neural arc) and from SNA to AP (peripheral arc). The transfer function from AVNS to SNA strikingly resembled the baroreflex neural arc and the transfer functions of SNA to AP were indistinguishable whether we perturbed ANVS or CSP, indicating that they likely share common central and peripheral neural mechanisms. To examine the impact of AVNS on baroreflex, we changed CSP stepwise and measured SNA and AP responses with or without AVNS. AVNS resets the sigmoidal neural arc downward, but did not affect the linear peripheral arc. In conclusion, AVNS resets the baroreflex neural arc and induces sympathoinhibition in the same manner as the control of SNA and AP by the native baroreflex.

摘要

已证实迷走神经刺激(VNS)对心力衰竭患者和/或动物有益。然而,VNS对交感神经活动(SNA)的影响仍不清楚。在本研究中,我们调查了迷走神经传入刺激(AVNS)如何影响SNA的压力反射控制。在12只麻醉的Sprague-Dawley大鼠中,我们控制孤立双侧颈动脉窦压力(CSP),并测量内脏SNA和动脉压(AP)。在恒定CSP下,增加AVNS电压会剂量依赖性地降低SNA和AP。SNA的平均最大抑制率为-28.0±10.3%。为了评估AVNS对SNA的动态影响,我们使用二进制白噪声序列进行随机AVNS,并确定从AVNS到SNA以及从SNA到AP的传递函数。我们还确定了从CSP到SNA(神经弧)和从SNA到AP(外周弧)的天然压力反射的传递函数。从AVNS到SNA的传递函数与压力反射神经弧惊人地相似,并且无论我们干扰AVNS还是CSP,SNA到AP的传递函数都无法区分,这表明它们可能共享共同的中枢和外周神经机制。为了检查AVNS对压力反射的影响,我们逐步改变CSP,并测量有无AVNS时的SNA和AP反应。AVNS使S形神经弧向下重置,但不影响线性外周弧。总之,AVNS重置压力反射神经弧,并以与天然压力反射对SNA和AP的控制相同的方式诱导交感神经抑制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1d6/4270242/dc604c752ec6/phy2-2-e12136-g1.jpg

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