Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
Department of Anatomy and Physiology, The University of Melbourne, Melbourne, Australia.
Exp Physiol. 2024 Dec;109(12):2001-2005. doi: 10.1113/EP090866. Epub 2023 Sep 26.
Patients diagnosed with heart failure have high rates of mortality and morbidity. Based on promising preclinical studies, vagal nerve stimulation has been trialled in these patients using whole nerve electrical stimulation, but the results have been mixed. This is, at least in part, due to an inability to selectively recruit the activity of specific fibres within the vagus with whole nerve electrical stimulation, as well as not knowing which the 'therapeutic' fibres are. This symposium review focuses on a population of cardiac-projecting efferent vagal fibres with cell bodies located within the dorsal motor nucleus of the vagus nerve and a new method of selectively targeting these projections as a potential treatment in heart failure.
被诊断患有心力衰竭的患者具有较高的死亡率和发病率。基于有前景的临床前研究，已使用全神经电刺激对这些患者进行了迷走神经刺激试验，但结果喜忧参半。这至少部分归因于全神经电刺激无法选择性地募集迷走神经中特定纤维的活动，也不知道哪些纤维是“治疗性”纤维。本次专题讨论会的综述重点关注了位于迷走神经背核内的心脏传出迷走纤维群体，以及一种新的选择性靶向这些投射的方法，作为心力衰竭的潜在治疗方法。
