饮茶与肺癌风险：病例对照研究和队列研究的荟萃分析
Tea consumption and lung cancer risk: a meta-analysis of case-control and cohort studies.
作者信息
Wang Lanfang, Zhang Xingwei, Liu Jing, Shen Li, Li Zhiqiang
机构信息
Institute of Nutrition and Healthy Food, Tongji University School of Medicine, Shanghai, China.
Institute of Nutrition and Healthy Food, Tongji University School of Medicine, Shanghai, China.
出版信息
Nutrition. 2014 Oct;30(10):1122-7. doi: 10.1016/j.nut.2014.02.023. Epub 2014 Mar 12.
OBJECTIVE
Recent epidemiologic studies, especially cohort and case-control studies, have yielded inconsistent findings regarding the association between tea consumption and risk for lung cancer. The aim of this study was to assess a potential relationship between tea consumption and the incidence of lung cancer worldwide.
METHODS
A systematic literature search of PubMed, Web of Science, the Cochrane Library, Google Scholar, the Chinese Biomedical Database, and Wanfang Database was conducted from 1966 to January 2014 by two investigators. All cohort studies and case-control studies that evaluated the association of tea and lung cancer were included. Summary relative risks (RR) and the corresponding 95% confidence intervals (CIs) were calculated using a random-effects model. Quality assessments were performed using the Newcastle-Ottawa Scale. Heterogeneity was assessed using the Q and I(2) tests, and the source of heterogeneity was detected by meta-regression analysis. Publication bias was evaluated with Egger's regression symmetry test. Subgroup analyses and sensitivity analysis were performed.
RESULTS
Thirty-eight lung cancer studies (26 case-control studies and 12 cohort studies) with 59,041 cases and 396,664 controls were included. Overall tea consumption was significantly associated with decreased risk for lung cancer (RR, 0.78; 95% CI, 0.70-0.87). Subgroup analyses showed that tea consumption was associated with reduced risk for lung cancer in women (RR, 0.76; 95% CI, 0.62-0.93), case-control studies (RR 0.72; 95% CI 0.63-0.83), Western studies (RR, 0.85; 95% CI, 0.75-0.97), and studies in China and Japan (RR, 0.74; 95% CI, 0.62-0.88). Both green tea (RR, 0.75; 95% CI, 0.62-0.91) and black tea (RR, 0.82; 95% CI, 0.71-0.94) were significantly associated with reduced lung cancer risk. No significant association was found in men or in cohort studies.
CONCLUSION
Tea consumption may offer some protection against lung cancer.
目的
近期的流行病学研究，尤其是队列研究和病例对照研究，在饮茶与肺癌风险之间的关联方面得出了不一致的结果。本研究的目的是评估全球范围内饮茶与肺癌发病率之间的潜在关系。
方法
由两名研究人员于1966年至2014年1月对PubMed、科学网、考克兰图书馆、谷歌学术、中国生物医学数据库和万方数据库进行了系统的文献检索。纳入了所有评估茶与肺癌关联的队列研究和病例对照研究。使用随机效应模型计算汇总相对风险（RR）及相应的95%置信区间（CI）。采用纽卡斯尔-渥太华量表进行质量评估。使用Q检验和I²检验评估异质性，并通过Meta回归分析检测异质性来源。用Egger回归对称检验评估发表偏倚。进行亚组分析和敏感性分析。
结果
纳入了38项肺癌研究（26项病例对照研究和12项队列研究），涉及59041例病例和396664例对照。总体而言，饮茶与肺癌风险降低显著相关（RR，0.78；95%CI，0.70 - 0.87）。亚组分析表明，饮茶与女性肺癌风险降低有关（RR，0.76；95%CI，0.62 - 0.93）、病例对照研究（RR 0.72；95%CI 0.63 - 0.83）、西方研究（RR，0.85；95%CI，0.75 - 0.97）以及中国和日本的研究（RR，0.74；95%CI，0.62 - 0.88）。绿茶（RR，0.75；95%CI，0.62 - 0.91）和红茶（RR，0.82；95%CI，0.71 - 0.94）均与肺癌风险降低显著相关。在男性或队列研究中未发现显著关联。
结论
饮茶可能对肺癌有一定的预防作用。
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