Wu Shihao, Li Fei, Huang Xiao, Hua Qingsheng, Huang Tao, Liu Zhile, Liu Zhixiang, Zhang Zhaofei, Liao Chunxian, Chen Yuanxiang, Shi Yuqiang, Zeng Renchuang, Feng Mingen, Zhong Xintai, Long Zhaolin, Tan Wanlong, Zhang Xinji
Department of Urology, Shunde First People's Hospital, Southern Medical University, Guangdong, China.
Asia Pac J Clin Nutr. 2013;22(1):128-37. doi: 10.6133/apjcn.2013.22.1.15.
The association between tea consumption and bladder cancer has been confirmed in several animal studies, but one epidemiological study in 2001 showed no association between them. In order to provide an accurate assessment of this, we conducted a meta-analysis on tea consumption and bladder cancer risk. Studies were identified by a literature search in PubMed from January 1980 to March 2012 and the reference lists of relevant studies. Random effect models were used to calculate summary relative risk estimates (RR) and their corresponding 95% confidence intervals (CI) based on high contrast to low intake values. Twenty-four publications (6 cohort studies and 18 case-control studies) based on consumption of overall tea, black tea, and green tea to bladder cancer risk were included in this analysis. For overall tea, the summary RR indicated no association between tea consumption and bladder cancer (RR= 1.09, 95%CI: 0.85-1.40). In subgroup analyses, we found a moderate increase of bladder cancer risk in smoking group (RR= 1.77, 95%CI: 1.04-3.01). In the black tea group, no statistically significant association was observed (RR= 0.84, 95%CI: 0.70-1.01). Interestingly, in the subgroup of sex, a protective effect was observed between tea consumption and bladder cancer risk in female (RR= 0.61, 95%CI: 0.38- 0.98). For green tea group, there was no relationship associated with bladder cancer risk (RR= 1.03, 95%CI: 0.82- 1.31). In conclusion, our data suggest that high overall tea intake in smokers increased the risk of bladder cancer, and high black tea intake in female may reduce the risk of bladder cancer.
几项动物研究已证实饮茶与膀胱癌之间存在关联，但2001年的一项流行病学研究表明二者之间并无关联。为对此进行准确评估，我们对饮茶与膀胱癌风险进行了一项荟萃分析。通过检索1980年1月至2012年3月PubMed中的文献以及相关研究的参考文献列表来确定研究。基于高摄入量与低摄入量值，使用随机效应模型计算汇总相对风险估计值（RR）及其相应的95%置信区间（CI）。本分析纳入了24篇基于总体茶、红茶和绿茶消费与膀胱癌风险的出版物（6项队列研究和18项病例对照研究）。对于总体茶，汇总RR表明饮茶与膀胱癌之间无关联（RR = 1.09，95%CI：0.85 - 1.40）。在亚组分析中，我们发现吸烟组膀胱癌风险有适度增加（RR = 1.77，95%CI：1.04 - 3.01）。在红茶组中，未观察到统计学上显著的关联（RR = 0.84，95%CI：0.70 - 1.01）。有趣的是，在性别亚组中，观察到女性饮茶与膀胱癌风险之间存在保护作用（RR = 0.61，95%CI：0.38 - 0.98）。对于绿茶组，与膀胱癌风险无关联（RR = 1.03，95%CI：0.82 - 1.31）。总之，我们的数据表明吸烟者大量饮用总体茶会增加膀胱癌风险，而女性大量饮用红茶可能会降低膀胱癌风险。
