Ryu Chung-Kyu, Oh Sun Young, Choi Soo Jung, Kang Da Young
College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University.
Chem Pharm Bull (Tokyo). 2014;62(11):1119-24. doi: 10.1248/cpb.c14-00527. Epub 2014 Sep 5.
2H-[1,2,3]Triazolo[4,5-g]isoquinoline-4,9-diones and 2H-[1,2,3]triazolo[4,5-g]quinoline-4,9-diones were synthesized and tested for in vitro antifungal activity against pathogenic fungi. Many of those synthesized showed potent antifungal activity. Compounds 3a, 3b, 3g, and 3h completely inhibited the growth of all fungal species tested at the MIC level of 0.8-12.5 µg/mL. The results suggest that 2H-[1,2,3]triazolo[4,5-g]isoquinoline-4,9-diones could be antifungal agents.
合成了2H-[1,2,3]三唑并[4,5-g]异喹啉-4,9-二酮和2H-[1,2,3]三唑并[4,5-g]喹啉-4,9-二酮，并测试了它们对致病真菌的体外抗真菌活性。所合成的许多化合物显示出强效抗真菌活性。化合物3a、3b、3g和3h在0.8-12.5 µg/mL的最低抑菌浓度水平下完全抑制了所有测试真菌物种的生长。结果表明，2H-[1,2,3]三唑并[4,5-g]异喹啉-4,9-二酮可能是抗真菌剂。
