Rucevic Marijana, Boucau Julie, Dinter Jens, Kourjian Georgio, Le Gall Sylvie
Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA 02139, USA.
Viruses. 2014 Aug 21;6(8):3271-92. doi: 10.3390/v6083271.
The degradation of HIV-derived proteins into epitopes displayed by MHC-I or MHC-II are the first events leading to the priming of HIV-specific immune responses and to the recognition of infected cells. Despite a wealth of information about peptidases involved in protein degradation, our knowledge of epitope presentation during HIV infection remains limited. Here we review current data on HIV protein degradation linking epitope production and immunodominance, viral evolution and impaired epitope presentation. We propose that an in-depth understanding of HIV antigen processing and presentation in relevant primary cells could be exploited to identify signatures leading to efficient or inefficient epitope presentation in HIV proteomes, and to improve the design of immunogens eliciting immune responses efficiently recognizing all infected cells.
人类免疫缺陷病毒（HIV）衍生蛋白降解为主要组织相容性复合体I类（MHC-I）或II类（MHC-II）所呈递的表位，是引发HIV特异性免疫反应及识别受感染细胞的首要事件。尽管关于参与蛋白质降解的肽酶已有大量信息，但我们对HIV感染期间表位呈递的了解仍然有限。在此，我们综述了有关HIV蛋白降解与表位产生及免疫显性、病毒进化和表位呈递受损之间关系的现有数据。我们提出，深入了解HIV在相关原代细胞中的抗原加工和呈递过程，有助于识别HIV蛋白质组中导致表位呈递高效或低效的特征，并改进免疫原的设计，从而引发能有效识别所有受感染细胞的免疫反应。
