Marsh Anne, Schiffelers Raymond, Kuypers Frans, Larkin Sandra, Gildengorin Ginny, van Solinge Wouter, Hoppe Carolyn
Department of Hematology/Oncology, UCSF Benioff Children's Hospital Oakland, Oakland, CA, USA; Children's Hospital Oakland Research Institute, Oakland, CA, USA.
Br J Haematol. 2015 Jan;168(1):135-8. doi: 10.1111/bjh.13110. Epub 2014 Sep 6.
Osteonecrosis of the femoral head (ONFH) is a common complication of sickle cell disease (SCD). To examine the association between microparticles and ONFH in SCD, we compared plasma microparticle levels in 20 patients with and without ONFH. Microparticles were quantified using nanoparticle tracking analysis and found to be 2·3-fold higher in patients with ONFH compared to patients without ONFH, and 2·5-fold higher than in healthy controls. These results suggest that microparticles may be a clinically useful biomarker of ONFH in SCD. Further investigations are needed to determine the functional relevance of microparticles in the pathogenesis of ONFH in SCD.
股骨头坏死（ONFH）是镰状细胞病（SCD）的常见并发症。为了研究微粒与SCD中ONFH之间的关联，我们比较了20例有和没有ONFH的患者的血浆微粒水平。使用纳米颗粒跟踪分析对微粒进行定量，发现有ONFH的患者的微粒水平比没有ONFH的患者高2.3倍，比健康对照高2.5倍。这些结果表明，微粒可能是SCD中ONFH的一种临床有用的生物标志物。需要进一步研究以确定微粒在SCD中ONFH发病机制中的功能相关性。
