Mohajeri Gholamreza, Safaee Masumeh, Sanei Mohamad Hossein
Department of Thoracic Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2014 Jun;19(6):520-4.
Kiwifruit (Actindia Deliciosa) is demonstrated to have antibacterial and pro-angiogenic effects. It also contains proteolytic enzymes (actinidin) and ascorbic acid. In this study, the effects of Kiwifruit on neuropathic diabetic foot ulcer healing in clinical settings were evaluated.
In this randomized clinical trial of 37 patients (17 in experimental and 20 in control groups) with neuropathic diabetic foot ulcer were studied in Isfahan-Iran. Patients of the control group received just the standard treatments. In the experimental group, in addition to the standard treatments, ulcers were dressed with pure extract of kiwifruit twice daily for 21 days. The ulcers were examined and evaluated based on macroscopic, microscopic and microbiological status. Pre- and post-interventions, biopsies were taken from the ulcers to perform microbiological and histological studies.
Mean reduction in surface area of foot ulcer in the experimental group was significantly higher than the control group (168.11 ± 22.31 vs. 88.80 ± 12.04 mm(2) respectively, P < 0.0001). The amount of collagen and granulation tissues was significantly higher in the experimental groups than the control group (P value < 0.0001). Significantly higher levels of angiogenesis and vascularization were found in the kiwifruit treated patients (P value < 0.0001). No significant antibacterial effect was observed for kiwifruit.
Natural compounds in the kiwifruit including protein-dissolving enzymes (Actinidin) improved different aspects of the wound healing process. Based on these benefits and safety aspects, we conclude that using kiwifruit is a simple, applicable and effective way for treatment of neuropathic diabetic foot ulcer.
已证明猕猴桃（中华猕猴桃）具有抗菌和促血管生成作用。它还含有蛋白水解酶（猕猴桃碱）和抗坏血酸。在本研究中，评估了猕猴桃在临床环境中对糖尿病神经病变性足部溃疡愈合的影响。
在伊朗伊斯法罕进行的这项随机临床试验中，研究了37例糖尿病神经病变性足部溃疡患者（实验组17例，对照组20例）。对照组患者仅接受标准治疗。在实验组中，除标准治疗外，溃疡每天用猕猴桃纯提取物换药两次，持续21天。根据宏观、微观和微生物学状况对溃疡进行检查和评估。干预前后，从溃疡处取活检组织进行微生物学和组织学研究。
实验组足部溃疡表面积的平均减少量显著高于对照组（分别为168.11±22.31与88.80±12.04平方毫米，P<0.0001）。实验组的胶原蛋白和肉芽组织量显著高于对照组（P值<0.0001）。在接受猕猴桃治疗的患者中发现血管生成和血管化水平显著更高（P值<0.0001）。未观察到猕猴桃有显著的抗菌作用。
猕猴桃中的天然化合物，包括蛋白溶解酶（猕猴桃碱），改善了伤口愈合过程的不同方面。基于这些益处和安全性方面，我们得出结论，使用猕猴桃是治疗糖尿病神经病变性足部溃疡的一种简单、适用且有效的方法。
