Rafsanjan University of Medical Sciences, Rafsanjan, Islamic Republic of Iran.
Int J Low Extrem Wounds. 2021 Jun;20(2):104-110. doi: 10.1177/1534734619851700. Epub 2021 Feb 2.
Diabetes mellitus is considered a silent disease with possible late chronic complications such as diabetic foot ulcer. This condition is managed by surgical debridement. To improve surgical outcome, some surgeons use proteolytic agents after surgery. Kiwifruit contains a type of proteolytic enzyme called actinidin that may play a role in the treatment of such complication. In the current study, we evaluate the role of kiwifruit extract in the treatment of diabetic foot ulcer. Eighteen diabetic foot ulcer patients were included in a randomized, double-blind clinical trial. The patients were divided randomly to control and experimental groups. Patients in the control group underwent daily wound dressing using base ointment (Eucerin). In the experimental group, we added kiwifruit extract to the standard wound dressing. Clinical data including general appearance of wound (according to recorded photographs before and after medical intervention) were analyzed using SPSS version 22. The mean wound area of the experimental group was significantly less than in the control group ( = .005) after 4 weeks of treatment. Comparison of the average of size difference, before and after the treatment in the experimental group and the control group, shows that kiwifruit can have a good impact on wound healing ( = .0001). In patients with diabetic foot ulcer, wound dressing using kiwifruit extract may help reduce time of treatment and may replace surgical debridement for some selected cases.
糖尿病被认为是一种无声的疾病，可能会出现糖尿病足溃疡等慢性并发症。这种情况需要通过手术清创来治疗。为了提高手术效果，一些外科医生在手术后使用蛋白水解剂。猕猴桃含有一种叫做过氧化物酶的蛋白水解酶，可能在治疗这种并发症方面发挥作用。在目前的研究中，我们评估了猕猴桃提取物在治疗糖尿病足溃疡中的作用。18 例糖尿病足溃疡患者被纳入一项随机、双盲临床试验。患者被随机分为对照组和实验组。对照组患者每天使用基础软膏（优色林）进行伤口包扎。在实验组中，我们在标准伤口敷料中加入了猕猴桃提取物。使用 SPSS 版本 22 分析包括伤口一般外观（根据医疗干预前后记录的照片）在内的临床数据。实验组的平均伤口面积在治疗 4 周后明显小于对照组（= 0.005）。实验组和对照组治疗前后平均大小差异的比较表明，猕猴桃对伤口愈合有很好的影响（= 0.0001）。在糖尿病足溃疡患者中，使用猕猴桃提取物进行伤口包扎可能有助于减少治疗时间，并可能替代某些选定病例的手术清创。
