Herman Anna, Herman Andrzej Przemysław
Chair of Drug and Cosmetics Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Koszykowa 75 Street, 00-662 Warsaw, Poland.
Department of Genetic Engineering, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110 Jabłonna, Poland.
Pharmaceutics. 2023 Jan 14;15(1):281. doi: 10.3390/pharmaceutics15010281.
The purpose of this review is to provide verified data on the current knowledge acquired in preclinical and clinical studies regarding topically used herbal products and their active constituents (formulations and dressings) with diabetic wound healing activity. Moreover, herbal products and their active constituents used for diabetic wound infections, and various cellular and molecular mechanisms of their actions will also be described. The electronic databases were searched for articles published from 2012 to 2022. Publications with oral or systemic administration of herbal products in diabetic wound healing, published before 2012, available only as an abstract, or in languages other than English were excluded from the study. The 59 articles comparing topically used herbal products in diabetic wound healing treatment versus control treatments (placebo or active therapy) were selected. Herbal products through different mechanisms of action, including antimicrobial, anti-inflammatory, antioxidant activity, stimulation of angiogenesis, production of cytokines and growth factors, keratinocytes, and fibroblast migration and proliferation may be considered as an important support during conventional therapy or even as a substitute for synthetic drugs used for diabetic wound treatment.
本综述的目的是提供经证实的数据，内容涉及在临床前和临床研究中获得的有关局部使用的草药产品及其具有糖尿病伤口愈合活性的活性成分（制剂和敷料）的当前知识。此外，还将描述用于糖尿病伤口感染的草药产品及其活性成分，以及它们作用的各种细胞和分子机制。检索了2012年至2022年发表的文章的电子数据库。2012年以前发表的、仅以摘要形式提供的、或以英语以外的语言发表的关于口服或全身给药的草药产品在糖尿病伤口愈合中的应用的出版物被排除在研究之外。选择了59篇比较局部使用草药产品与对照治疗（安慰剂或活性治疗）在糖尿病伤口愈合治疗中的文章。草药产品通过不同的作用机制，包括抗菌、抗炎、抗氧化活性、刺激血管生成、细胞因子和生长因子的产生、角质形成细胞以及成纤维细胞迁移和增殖，可被视为传统治疗期间的重要支持，甚至可替代用于糖尿病伤口治疗的合成药物。
