Lippert Frank, Hara Anderson Takeo, Martinez-Mier Esperanza Angeles, Zero Domenick T
Department of Preventive and Community Dentistry, Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, Ind., USA.
Pediatr Dent. 2014 Jul-Aug;36(4):291-5.
The purpose of this study was to investigate the potential anticaries efficacy of fluoride varnishes (FVs) by studying their ability to reharden and deliver fluoride to carious lesions and to release fluoride into saliva.
Enamel carious lesions were created and allocated to 24 groups (11 FVs with two FV incubation times and two control groups) based on Knoop microhardness test values. FVs were applied to lesions, which were incubated in artificial saliva for two or six hours, with saliva being renewed hourly. FV was removed and lesions were remineralized in artificial saliva for 22 hours. Microhardness was measured and enamel fluoride uptake (EFU) was determined. Saliva samples (six-hour groups) were analyzed to determine fluoride release characteristics. Data were analyzed using analysis of variance.
FVs differed considerably in their ability to reharden and deliver fluoride to carious lesions and in their fluoride release characteristics. Little consistency was found between investigated study variables for virtually all tested FVs. For example, a particular FV showed the highest EFU and fluoride release values but the lowest rehardening value. A longer FV contact time led to increased EFU for five of the 11 FVs. Some FVs delivered more fluoride to lesions in two hours than others did in six hours.
Fluoride varnishes differ greatly in their in vitro anticaries efficacy.
本研究的目的是通过研究氟化物漆（FV）使龋损再矿化并向龋损输送氟以及向唾液中释放氟的能力，来调查其潜在的防龋效果。
制备釉质龋损，并根据努氏显微硬度测试值将其分为24组（11种氟化物漆，有两种FV孵育时间，以及两个对照组）。将氟化物漆应用于龋损，在人工唾液中孵育两小时或六小时，每小时更换一次唾液。去除氟化物漆后，龋损在人工唾液中再矿化22小时。测量显微硬度并测定釉质氟摄取量（EFU）。分析唾液样本（六小时组）以确定氟释放特征。使用方差分析对数据进行分析。
氟化物漆在使龋损再矿化并向龋损输送氟的能力以及氟释放特征方面存在很大差异。几乎所有测试的氟化物漆在研究变量之间几乎没有发现一致性。例如，一种特定的氟化物漆显示出最高的EFU和氟释放值，但再矿化值最低。11种氟化物漆中有5种，FV接触时间延长导致EFU增加。一些氟化物漆在两小时内输送到龋损的氟比其他氟化物漆在六小时内输送的还多。
氟化物漆的体外防龋效果差异很大。
