Horak Pavel, Skacelova Martina, Zadrazil Josef, Smrzova Andrea, Krejcí Karel, Ciferska Hana, Hermanova Zuzana
III Department of Internal Medicine, Faculty of Medicine and Dentistry, Palacky University of Olomouc, I.P. Pavlova 6, 772 00 Olomouc, Czech Republic.
Curr Rheumatol Rev. 2013;9(1):34-44. doi: 10.2174/1573397111309010009.
SLE is characterized by overproduction of various types of autoantibodies. Under certain circumstances, antibodies targeting some of the neoepitopes of the complement system can be seen. The most studied among antibodies directed against a component of the complement system is anti-C1q. Anti-C1q antibodies are present in approximately one third of the patients with lupus, who often have high clinical disease activity and in particular renal involvement. In the presence of high titers of anti-C1q antibodies also the levels of C1q and C3 and C4 components of the complement system are also usually low. The presence of the anti-C1q antibodies is not limited or specific just for SLE or lupus nephritis. For the first time, they were described in HUVS (Hypocomplementemic Urticarial Vasculitis Sydrome), later in Felty´s syndrome, rheumatoid vasculitis, hepatitis C, poststreptococcal glomerulonephritis or aging population.
系统性红斑狼疮的特征是多种自身抗体产生过多。在某些情况下，可以看到针对补体系统一些新表位的抗体。在针对补体系统成分的抗体中，研究最多的是抗C1q抗体。约三分之一的狼疮患者存在抗C1q抗体，这些患者通常具有较高的临床疾病活动度，尤其是肾脏受累。在抗C1q抗体高滴度存在的情况下，补体系统的C1q、C3和C4成分水平通常也较低。抗C1q抗体的存在并不局限于系统性红斑狼疮或狼疮性肾炎，也不具有特异性。它们首次在低补体血症性荨麻疹性血管炎综合征中被描述，后来在费尔蒂综合征、类风湿性血管炎、丙型肝炎、链球菌感染后肾小球肾炎或老年人群中也有发现。
