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基于用G-四链体脱氧核酶和鲁米诺修饰的多功能金纳米颗粒的端粒酶活性的可视化电化学发光检测

Visual electrochemiluminescence detection of telomerase activity based on multifunctional Au nanoparticles modified with G-quadruplex deoxyribozyme and luminol.

作者信息

Zhang Huai-Rong, Wang Yin-Zhu, Wu Mei-Sheng, Feng Qiu-Mei, Shi Hai-Wei, Chen Hong-Yuan, Xu Jing-Juan

机构信息

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.

出版信息

Chem Commun (Camb). 2014 Oct 25;50(83):12575-7. doi: 10.1039/c4cc06302c.

DOI:10.1039/c4cc06302c
PMID:25199068
Abstract

A novel visual electrochemiluminescence (ECL) analysis strategy for detection of telomerase activity is reported on a microarray chip, with G-quadruplex deoxyribozyme (DNAzyme) and luminol modified Au nanoparticles (NPs) as double-catalytic amplification labels.

摘要

报道了一种在微阵列芯片上检测端粒酶活性的新型视觉电化学发光（ECL）分析策略，该策略以G-四链体脱氧核酶（DNAzyme）和鲁米诺修饰的金纳米颗粒（NPs）作为双催化放大标记物。

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