Anagnostakos Konstantinos, Schmitt Eduard, Orth Patrick
Orthopedics. 2014 Aug;37(8):e750-3. doi: 10.3928/01477447-20140728-94.
A 57-year-old man presented to the authors' department with pain over the right hip joint over a 3-month period. External magnetic resonance imaging showed a structure in the right acetabulum that was highly suspicious for a bone sarcoma. External 3-phase bone scintigraphy substantiated the suspected diagnosis. A computer tomography-guided biopsy was performed. Microbiologic examination showed a Staphylococcus aureus strain. Histopathologic findings showed chronic fibrous osteomyelitis. Because of doubts about these findings made by radiologists, open biopsy with retrieval of bony samples from the acetabulum and hip joint puncture was repeated. At that time, the serum C-reactive protein level was 48.8 mg/dL and the white blood cell count was 5600 × 10⁶/L. Microbiologic examination showed a S aureus and a Staphylococcus epidermidis strain in both regions. Results of blood cultures were negative. Based on these findings, the decision was made to perform a septic femoral head and neck resection. After meticulous debridement, necrosectomy, and pulsatile lavage, a gentamicin and vancomycin-impregnated cement spacer was implanted. Postoperatively, systemic antibiotic treatment with cefuroxime and rifampicin was administered for 4 weeks, followed by 2 weeks of oral antibiotics. Mobilization was allowed under toe-touch bearing of the operated extremity. The further postoperative course was uneventful. Prosthesis implantation was performed after 3 months. White blood cell count and C-reactive protein values were normal at the time of surgery. Histologic and microbiologic examination of tissue samples taken intraoperatively showed no evidence of persistent infection. At follow-up after 1 year, the patient had no complaints and has no local or systemic signs of infection.
一名57岁男性因右髋关节疼痛3个月就诊于作者所在科室。外部磁共振成像显示右髋臼有一结构,高度怀疑为骨肉瘤。外部三相骨闪烁显像证实了疑似诊断。进行了计算机断层扫描引导下的活检。微生物学检查显示为金黄色葡萄球菌菌株。组织病理学检查结果显示为慢性纤维性骨髓炎。由于放射科医生对这些检查结果存在疑问,遂再次进行开放性活检,从髋臼和髋关节穿刺获取骨样本。当时,血清C反应蛋白水平为48.8mg/dL,白细胞计数为5600×10⁶/L。微生物学检查显示两个部位均有金黄色葡萄球菌和表皮葡萄球菌菌株。血培养结果为阴性。基于这些检查结果,决定进行化脓性股骨头和颈部切除术。经过细致的清创、坏死组织清除和脉冲冲洗后,植入了含庆大霉素和万古霉素的骨水泥间隔物。术后,使用头孢呋辛和利福平进行了4周的全身抗生素治疗,随后口服抗生素2周。允许在术侧肢体脚尖触地负重的情况下进行活动。术后进一步病程顺利。3个月后进行了假体植入。手术时白细胞计数和C反应蛋白值均正常。术中获取的组织样本的组织学和微生物学检查未显示持续感染的迹象。随访1年后,患者无不适主诉,无局部或全身感染体征。