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用于两阶段感染性髋关节置换术的临时载抗生素骨水泥假体

[Temporary antibiotic-loaded cemented prosthesis for two-stage septic hip arthroplasty].

作者信息

Migaud H, Chantelot C, Besson A, Gougeon F, Dubois H H, Duquennoy A

机构信息

Service d'Orthopédie-Traumatologie B, Hôpital B, C.H.R.U. de Lille.

出版信息

Rev Chir Orthop Reparatrice Appar Mot. 1997;83(5):466-8.

PMID:9452800
Abstract

PURPOSE OF THE STUDY

During the excision period of a two-stage revision arthroplasty, the hip has a low function and an unacceptable leg length discrepancy. The goal of this study was to expose technical details in order to perform a simple articulated cement spacer which could be implanted during this period to improve hip function, to authorize partial weight bearing and to avoid leg length discrepancy.

MATERIAL

This method was applied in three two-stage procedures justified because of particular immunodeficiency conditions: a 43 years old man who had bone marrow allograft and immunosuppressive therapy because of leukemia suffering of subacute septic hip arthritis; a 58 years old man suffering of diabetes and active C-hepatitis who had a septic loosening of a total hip arthroplasty (THA); a 76 years old woman suffering of diabetes who had a third septic loosening of THA.

METHOD

The prosthesis was made of antibiotic-impregnated cement according to organisms antibiotic resistance. The prosthetic junction between head and diaphysis was reinforced with a tibial plate. Prosthetic shape was identical to the one of femoral broaches inserted in the femur after prosthetic and cement removal. The broach size was chosen when mechanical stability in the femur was obtained, and avoided leg length discrepancy after trials with cups. The tibial plate was bent in order to reinforce the junction with regard to the shape of the determined broach. Two doses of antibiotic-impregnated cement were mixed and molded with hands, then the plate was incorporated at the appropriate location, finally the broach was applied on this composite and cement in excess was removed before polymerisation. For prosthetic head, two options were available: to mold the cephalic zone of the cement at the patient acetabulum diameter with a soft aluminium cup previously molded in the acetabulum; to mold the cement cephalic zone with a trial cup in order to obtain a 22 or 28 ball. For this last option, a third dose of antibiotic-impregnated cement was prepared and placed in the acetabulum, a trial femoral head was applied in it to mold the location for the 22 or 28 prosthetic head. Before insertion, a collar was applied on the stem to prevent migration. Active mobilization was encouraged, and partial weight-bearing authorized.

RESULTS

The mean range of hip flexion during period was 60 degrees. The patients were discharged approximatively 12 days after the first stage. Two patients had effective painless partial weight-bearing. The second stage was performed six weeks later on the average. The second procedure was easier than the second stage of a conventional two-stage procedure because of: easy and low hemorrhagic dissection authorized by the prosthesis; low difficulties with soft tissue tension as the prosthesis prevents leg length discrepancy; preservation of the articular space which prevents soft tissue sacrifice during the second stage.

CONCLUSION

This simple technique is effective to prevent complications related to the excision period of a two-stage hip revision arthroplasty. Likewise, the economical aspect (short delay of hospitalisation, quick functional recovery) should be considered when compared with the excision period of a conventional two-stage procedure.

摘要

研究目的

在两阶段翻修关节成形术的切除阶段,髋关节功能低下且下肢长度差异难以接受。本研究的目的是揭示技术细节,以便制作一种简单的可在该阶段植入的关节式骨水泥间隔物,以改善髋关节功能,允许部分负重并避免下肢长度差异。

材料

该方法应用于因特殊免疫缺陷情况而进行的三个两阶段手术:一名43岁男性,因白血病接受骨髓同种异体移植和免疫抑制治疗,患有亚急性化脓性髋关节炎;一名58岁男性,患有糖尿病和活动性丙型肝炎,全髋关节置换术(THA)发生感染性松动;一名76岁女性,患有糖尿病,THA发生第三次感染性松动。

方法

根据生物体的抗生素耐药性,假体由含抗生素的骨水泥制成。头部和骨干之间的假体连接处用胫骨板加强。假体形状与假体和骨水泥取出后插入股骨的股骨拉刀相同。当在股骨中获得机械稳定性时选择拉刀尺寸,并在使用髋臼杯进行试验后避免下肢长度差异。胫骨板弯曲以根据确定的拉刀形状加强连接处。将两剂含抗生素的骨水泥混合并用手塑形,然后将板放置在适当位置,最后将拉刀应用于该复合材料上,并在聚合前去除多余的骨水泥。对于假体头部,有两种选择:用预先在髋臼中塑形的软铝杯在患者髋臼直径处塑形骨水泥的头部区域;用试验杯塑形骨水泥头部区域以获得22或28的球头。对于最后一种选择,制备第三剂含抗生素的骨水泥并放置在髋臼中,将试验股骨头应用于其中以塑形22或28假体头部的位置。插入前,在柄上应用一个环以防止移位。鼓励积极活动,并允许部分负重。

结果

在此期间髋关节屈曲的平均范围为60度。患者在第一阶段后约12天出院。两名患者有效无痛地进行了部分负重。第二阶段平均在六周后进行。由于以下原因,第二次手术比传统两阶段手术的第二阶段更容易:假体允许轻松且出血少的解剖;由于假体防止下肢长度差异,软组织张力方面的困难较小;保留关节间隙可防止在第二阶段牺牲软组织。

结论

这种简单技术有效地预防了与两阶段髋关节翻修关节成形术切除阶段相关的并发症。同样,与传统两阶段手术的切除阶段相比,应考虑经济方面(住院时间短、功能恢复快)。

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