Tsambaos D, Sampalis F, Berger H
Department of Dermatology, University of Patras, Greece.
Exp Cell Biol. 1989;57(6):292-9. doi: 10.1159/000163541.
The skin of hairless (Ng/Bln) mice topically treated with dimethylbenzanthracene (DMBA) was investigated by light microscopy, histochemistry, electron microscopy and autoradiography in order to gain some insight into the mechanisms by which the DMBA-induced cutaneous hyperpigmentation is mediated. The results of the present study indicate that this phenomenon is due to the DMBA-induced stimulation of both the tyrosinase system and the mitotic activity of dopa-inactive dormant melanocytes.
为了深入了解二甲基苯并蒽（DMBA）诱导皮肤色素沉着的介导机制，对用DMBA局部处理的无毛（Ng/Bln）小鼠皮肤进行了光学显微镜、组织化学、电子显微镜和放射自显影研究。本研究结果表明，这种现象是由于DMBA对酪氨酸酶系统和多巴无活性休眠黑素细胞有丝分裂活性的刺激所致。
