Ruben R L
Experientia. 1982 May 15;38(5):612-4. doi: 10.1007/BF02327079.
Skin patches on hibernating and nonhibernating ground squirrels were treated with multiple topical applications of the carcinogen 7,12-dimethylbenza(a)anthracene. Nonhibernators showed blistering, peeling, drying, hair loss, increased vascularization and hyperpigmentation in proportion to DMBA concentration. The latter was apparently due to a) an increased number of dermal and epidermal melanocytes and b) the appearance of melanocytes with large coarse cytoplasmic granules. Notably, hibernators remained free of gross skin changes and were histologically similar to untreated controls.
对冬眠和非冬眠的地松鼠的皮肤贴片进行多次局部涂抹致癌物质7,12-二甲基苯并(a)蒽处理。非冬眠动物会出现水泡、脱皮、干燥、脱发、血管增生和色素沉着，且与二甲基苯并蒽的浓度成比例。后者显然是由于：a) 真皮和表皮黑素细胞数量增加；b) 出现具有粗大细胞质颗粒的黑素细胞。值得注意的是，冬眠动物的皮肤未出现明显变化，组织学上与未处理的对照相似。
