Wang Ling, Wang Yong-Jun, Liu Yin-Yin, Li Hui, Guo Ling-Xia, Liu Zhong-Hua, Shi Xiao-Liu, Hu Min
The Second Xiangya Hospital of Central South University, Changsha, China.
College of Life Sciences, Hunan Normal University, Changsha, China.
Antimicrob Agents Chemother. 2014 Nov;58(11):6999-7002. doi: 10.1128/AAC.03279-14. Epub 2014 Sep 8.
The resistance of multidrug-resistant Acinetobacter baumannii (MDRAB) isolates to most traditional antibiotics results in huge challenges for infection therapy. We investigated the in vitro activities of both l- and d-lycosin-I against MDRAB. These two compounds displayed high antibacterial activities and rapid bactericidal effects against MDRAB. Moreover, the compounds retained their activity even at high salt (Mg(2+) or Ca(2+)) concentrations. These results demonstrate the potential of lycosin-I to be developed as a new antibiotic.
多重耐药鲍曼不动杆菌（MDRAB）分离株对大多数传统抗生素具有耐药性，这给感染治疗带来了巨大挑战。我们研究了l-和d-溶菌素-I对MDRAB的体外活性。这两种化合物对MDRAB显示出高抗菌活性和快速杀菌作用。此外，即使在高盐（Mg(2+)或Ca(2+)）浓度下，这些化合物仍保持其活性。这些结果证明了溶菌素-I作为一种新型抗生素被开发的潜力。
