Sarvaiya Jayrajsinh, Agrawal Y K
Institute of Research and Development, Gujarat Forensic Sciences University, Gandhinagar, India.
Institute of Research and Development, Gujarat Forensic Sciences University, Gandhinagar, India.
Int J Biol Macromol. 2015 Jan;72:454-65. doi: 10.1016/j.ijbiomac.2014.08.052. Epub 2014 Sep 6.
Chitosan, a biocompatible natural polysaccharide is frequently reported carrier material in targeted drug delivery to treat neurodegenerative disorders. Chitosan and its biodegradable products exert its bioactivities on nerve cells and blood brain barrier at the molecular level, which are beneficial in anti-Alzheimer therapy. Flexibility of surface modification, the ability to get attached with varieties of ligand molecules and the formation of the stable nano complex in physiological condition make chitosan an adorable material for delivery of anti-Alzheimer drugs and siRNA to the brain. The success rate of nose to brain delivery of anti-Alzheimer drugs enhances when chitosan used as a carrier material. This review covers direct and indirect anti-Alzheimer effects of chitosan, surface modification strategies to augment permeation from the blood-brain barrier structure, different ligands reported for brain targeting of chitosan nanoparticles containing anti Alzheimer drugs, blood compatibility and widely utilized chitosan nanoparticle fabrication techniques. Key intellectual claims are also condensed through patents to appraise chitosan as an attractive polymer for brain targeted nanoformulation which is currently facing oversight by regulatory agencies and manufacturers.
壳聚糖是一种生物相容性天然多糖，在靶向药物递送治疗神经退行性疾病方面经常被报道为载体材料。壳聚糖及其可生物降解产物在分子水平上对神经细胞和血脑屏障发挥生物活性，这在抗阿尔茨海默病治疗中是有益的。表面修饰的灵活性、与各种配体分子结合的能力以及在生理条件下形成稳定的纳米复合物，使壳聚糖成为将抗阿尔茨海默病药物和小干扰RNA递送至大脑的理想材料。当壳聚糖用作载体材料时，抗阿尔茨海默病药物鼻脑递送的成功率会提高。本综述涵盖了壳聚糖的直接和间接抗阿尔茨海默病作用、增强从血脑屏障结构渗透的表面修饰策略、报道用于含抗阿尔茨海默病药物的壳聚糖纳米颗粒脑靶向的不同配体、血液相容性以及广泛使用的壳聚糖纳米颗粒制备技术。还通过专利总结了关键的知识产权主张，以评估壳聚糖作为一种有吸引力的聚合物用于脑靶向纳米制剂，而目前该制剂正面临监管机构和制造商的忽视。
